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Published online by Cambridge University Press: 23 October 2025
In this paper, we will investigate the following inequality
\begin{equation*}(a_{n+1}a_{n+2} - a_{n}a_{n+3})^2 -(a_{n+1}^2 -a_{n}a_{n+2})(a_{n+2}^2 - a_{n}a_{n+4}) \gt 0,\end{equation*}
which arises from the iterated Laguerre operator on functions. We will prove the sequence
$\{a_n\}$ of a unified form given by Griffin, Ono, Rolen and Zagier asymptotically satisfies this inequality while the Maclaurin coefficients of the functions in Laguerre-Pólya class have not to possess this inequality. We also prove the companion version of this inequality. As a consequence, we show the Maclaurin coefficients of the Riemann Ξ-function asymptotically satisfy this property. Moreover, we make this approach effective and give the exact thresholds for the positivity of this inequalityfor the partition function, the overpartition function and the smallest part function.