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Physical Law and Mechanistic Explanation in the Hodgkin and Huxley Model of the Action Potential

Published online by Cambridge University Press:  01 January 2022

Carl F. Craver
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Abstract

Hodgkin and Huxley's model of the action potential is an apparent dream case of covering-law explanation in biology. The model includes laws of physics and chemistry that, coupled with details about antecedent and background conditions, can be used to derive features of the action potential. Hodgkin and Huxley insist that their model is not an explanation. This suggests either that subsuming a phenomenon under physical laws is insufficient to explain it or that Hodgkin and Huxley were wrong. I defend Hodgkin and Huxley against Weber's heteronomy thesis and argue that explanations are descriptions of mechanisms.

Type
Where Neuroscience Meets Physics: Laws, Explanation, and the Hodgkin-Huxley Model of the Action Potential
Information
Philosophy of Science , Volume 75 , Issue 5: Proceedings of the 2006 Biennial Meeting of the Philosophy of Science Association. Part II: Symposia Papers. Edited by Cristina Bicchieri and Jason Alexander , December 2008 , pp. 1022 - 1033
Copyright
Copyright © The Philosophy of Science Association

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Footnotes

‡

Thanks to Anna Alexandrova, Jim Bogen, Lindley Darden, Ken Schaffner, and Marcel Weber for comments and discussion.

References

Bechtel, W., and Abrahamson, A. (2005), “Explanation: A Mechanist Alternative”, in Carl F. Craver and Lindley Darden (eds.), “Mechanisms in Biology”, special issue, Studies in History and Philosophy of Biological and Biomedical Sciences 36:421–441.CrossRefGoogle Scholar
Bogen, J. (2005), “Regularities and Causality; Generalizations and Causal Explanations”, in Carl F. Craver and Lindley Darden (eds.), “Mechanisms in Biology”, special issue, Studies in History and Philosophy of Biological and Biomedical Sciences 36:397–420.CrossRefGoogle Scholar
Bogen, J. (2008), “The Hodgkin-Huxley Equations and the Concrete Model: Comments on Craver, Schaffner, and Weber”, The Hodgkin-Huxley Equations and the Concrete Model: Comments on Craver, Schaffner, and Weber 75, in this issue.Google Scholar
Cole, K. (1992), “‘Neuromembranes: Paths of Ions”, in Worden, F. G., Swazey, J. P., and Adelman, G. (eds.), Neurosciences, Paths of Discovery. vol. 1. Cambridge, MA: MIT Press.Google Scholar
Craver, C. F. (2007), Explaining the Brain: Mechanisms and the Mosaic Unity of Neuroscience. Oxford: Oxford University Press.CrossRefGoogle Scholar
Hempel, C. G. (1965), Aspects of Scientific Explanation and Other Essays in the Philosophy of Science. New York: Free Press.Google Scholar
Hille, B. (1992), Ion Channels of Excitable Membranes. 2nd ed. Sunderland, MA: Sinauer.Google Scholar
Hille, B., Armstrong, Clay, and MacKinnon, Roderick (1999), “Ion Channels: From Idea to Reality”, Ion Channels: From Idea to Reality 5:1105–1109.Google Scholar
Hodgkin, A. L. (1992), Chance and Design: Reminiscences of Science in Peace and War. Cambridge: Cambridge University Press.Google Scholar
Hodgkin, A. L., and Huxley, A. F. (1952), “A Quantitative Description of Membrane Current and Its Application to Conduction and Excitation in Nerve”, A Quantitative Description of Membrane Current and Its Application to Conduction and Excitation in Nerve 117:500–544.Google ScholarPubMed
Huxley, A. F. (1963), “The Quantitative Analysis of Excitation and Conduction in Nerve”, http://nobelprize.org/medicine/laureates/1963/huxley-lecture.html.Google Scholar
Machamer, P. K., Darden, L., and Craver, C. F. (2000), “Thinking about Mechanisms”, Thinking about Mechanisms 67:1–25.Google Scholar
Salmon, Wesley (1984), Scientific Explanation and the Causal Structure of the World. Princeton, NJ: Princeton University Press.Google Scholar
Weber, M. (2005), Philosophy of Experimental Biology. Cambridge: Cambridge University Press.Google Scholar
Weber, M. (2008), “Causes without Mechanisms: Experimental Regularities, Physical Laws, and Neuroscientific Explanation”, Causes without Mechanisms: Experimental Regularities, Physical Laws, and Neuroscientific Explanation 75, in this issue.Google Scholar
Woodward, J. (2003), Making Things Happen. New York: Oxford University Press.Google Scholar