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Vaccines against the zoonotic trematodes Schistosoma japonicum, Fasciola hepatica and Fasciola gigantica

Published online by Cambridge University Press:  02 February 2007

D. P. McMANUS  and
J. P. DALTON
D. P. McMANUS
Affiliation:
Molecular Parasitology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Q 4006, Australia
J. P. DALTON
Affiliation:
Institute for the Biotechnology of Infectious Diseases University of Technology Sydney (UTS), Level 6, Building 4, Harris Street & Thomas Street, Ultimo, Sydney, NSW 2007, Australia
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Abstract

Schistosoma japonicum, Fasciola hepatica and F. gigantica are digenetic trematodes and, therefore, possess similar life cycles. While schistosomiasis japonica has for a long time been recognised as a major disease of both humans and animals, infection with fasciolids has only been considered of relevance to animals. However, a number of recent reports indicate that fasciolosis is becoming a serious public health problem, especially in South America, Egypt and Iran (sporadic cases are also on the increase throughout Europe). Vaccines targeted at animals could play an important role in controlling these three diseases in animals and, by blocking transmission of infection, have a concurrent beneficial effect on disease in humans. Approaches towards identifying and producing vaccines against these parasites are similar and are discussed in this reveiw.

Keywords

Schistosoma japonicumschistosomiasis japonicaFasciola hepaticaFasciola giganticafasciolosistransmission blocking veterinary vaccineantigen discoveryrecombinant proteinsimmune responses
Type
Research Article
Information
Parasitology , Volume 133 , Supplement S2: Parasite Vaccines , October 2006 , pp. S43 - S61
Copyright
© 2006 Cambridge University Press

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