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Parasite vaccines – recent progress and problems associated with their development

Published online by Cambridge University Press:  02 February 2007

D. P. KNOX  and
D. L. REDMOND
D. P. KNOX
Affiliation:
Moredun Research Institute, International Research Centre, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, Scotland, UK.
D. L. REDMOND
Affiliation:
Moredun Research Institute, International Research Centre, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, Scotland, UK.
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Extract

The treatment and prevention of parasitism in both humans and livestock continues to rely almost exclusively on the use of antiparasitic drugs – an approach which has limitations, particularly as reinfection, which occurs rapidly in endemic regions, is not prevented. In addition, the widespread appearance of drug-resistant parasites of animals (Kaplan, 2004;) together with emerging evidence of resistance problems in human parasites (Fallon et al. 1995; Ismail et al. 1996; De Clerq et al. 1997; East African Network for Monitoring Antimalarial Treatment, 2003), emphasise the importance of developing alternative methods of control, with anti-parasite vaccines a prime target.

Keywords

Parasitevaccinationrecombinantsub-unit vaccine

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Overview
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Parasitology , Volume 133 , Supplement S2: Parasite Vaccines , October 2006 , pp. S1 - S8
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© 2006 Cambridge University Press

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