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Experiences with vaccines against cutaneous leishmaniasis: of men and mice

Published online by Cambridge University Press:  06 April 2009

Farrokh Modabber
Farrokh Modabber
Affiliation:
UNDP/World Bank WHO Special Programme for Research and Training in Tropical Diseases, World Health Organization, CH 1211, Geneva 27, Switzerland
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Summary

The need for a vaccine(s) against cutaneous leishmaniasis and the populations at risk for whom such vaccines should be developed are briefly discussed. The current human vaccine studies are reviewed, as are some experimental mouse studies with emphasis on Leishmania major infection relevant to vaccine development. Based on the information available from the mouse model and those data which are being sought in human studies, the benign nature of the cutaneous disease, the ease with which L. major can be manipulated to yield the required material, and the ongoing practice of leishmanization which allows rapid evaluation of candidate vaccine(s), it is suggested that a vaccine, at least against L. major, is imminent in the not too distant future.

Keywords

cutaneous leishmaniasisvaccinesLeishmania majorhumansmice

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Type
Research Article
Information
Parasitology , Volume 98 , supplement S1: Symposia of the British Society for Parasitology Volume 26:Vaccines and vaccination strategies , January 1989 , pp. S49 - S60
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Copyright © Cambridge University Press 1989

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