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Effects of cyclophosphamide and dexamethasone on mast cell populations in Hymenolepis microstoma-infected mice

Published online by Cambridge University Press:  06 April 2009

M. Novak ,
L. G. Buchannan  and
H. Howlader
M. Novak
Affiliation:
Department of BiologyUniversity of Winnipeg, Winnipeg, Manitoba, Canada R3B 2E9
L. G. Buchannan
Affiliation:
Department of BiologyUniversity of Winnipeg, Winnipeg, Manitoba, Canada R3B 2E9
H. Howlader
Affiliation:
Department of Statistics, University of Winnipeg, Winnipeg, Manitoba, Canada R3B 2E9
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Summary

Antineoplastic cyclophosphamide (CY) significantly reduced the survival and the weight of Hymenolepis microstoma in mice. Corticosteroid dexamethasone (DEX), on the other hand, did not influence the worm survival and the worms in DEX-treated mice became significantly heavier. Both immunosuppressants abolished H. microstoma-induced bile duct hypertrophy and submucous enteritis and lowered the number of mast cells (MC) in these regions. CY appeared to be more effective in depleting the bile duct MC whereas DEX seemed to affect more the duodenal MC population.

Keywords

Hymenolepis microstomamast cellscyclophosphamidedexamethasone
Type
Research Article
Information
Parasitology , Volume 100 , Issue 2 , April 1990 , pp. 337 - 343
Copyright
Copyright © Cambridge University Press 1990

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