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Survival, strobilation and sexual maturation of Echinococcus multilocularis in the small intestine of golden hamsters

Published online by Cambridge University Press:  06 April 2009

M. Kamiya  and
H. Sato
M. Kamiya
Affiliation:
Department of Parasitology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060, Japan
H. Sato
Affiliation:
Department of Parasitology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060, Japan
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Summary

Echinococcus multilocularis survived, strobilated and matured sexually in the small intestine of 6-week-old male golden hamsters that were either non-treated or treated with prednisolone tertiary-butylacetate (PTBA), following oral administration of 20000 protoscoleces. Non-treated hamsters harboured the adult worms for up to 25 days post-infection (p.i.). Hamsters treated with PTBA from the day of infection (day 0 p.i.) harboured more adults than the non-treated, and their survival periods were extended. Moreover, a remarkable improvement in worm recovery, development and survival periods was observed in hamsters additionally treated with PTBA on days — 14 and — 12 p.i., and the worm development including proglottisation, sexual maturation and egg formation was comparable with that in dogs. With the present results it is suggested that Echinococcus/rodent systems represented by the E. multilocularis/golden hamsters may rejuvenate the current stagnant research on host-parasite interactions of the definitive host-stage and egg-stage of Echinococcus.

Keywords

Echinococcus multilocularisgolden hamstersprednisolonealternative definitive hostexperimental model

Information

Type
Research Article
Information
Parasitology , Volume 100 , Issue 1 , February 1990 , pp. 125 - 130
Copyright
Copyright © Cambridge University Press 1990

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