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Study for the Interfacial Effect between a Crawling Cell and aSubstrate on Chemotaxis

Published online by Cambridge University Press:  10 March 2011

Jihwan Song  and
Dongchoul Kim
Jihwan Song
Affiliation:
Department of Mechanical Engineering, Sogang University, 1 Shinsoo-dong, Mapo-go, Seoul, Republic of Korea
Dongchoul Kim
Affiliation:
Department of Mechanical Engineering, Sogang University, 1 Shinsoo-dong, Mapo-go, Seoul, Republic of Korea
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Abstract

Chemotaxis is one of the essential mechanisms responsible for variouscomplex biological processes. For a crawling cell, the interface between thecell and the substrate plays an important role in the chemotactic migration.This paper presents a three-dimensional dynamic model to investigate theeffect of the interface between a crawling cell and a substrate on itschemotaxis. The coupled mechanisms of chemotaxis, the surface energy of thecell, and the interface between the cell and the substrate are incorporatedinto a diffuse interface model. Simulations reveal rich dynamics of acrawling cell associated with the interfacial condition, and confirm thehigh possibility of adequate predictions.

Keywords

biologicalsimulationdiffusion

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