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Selective Laser Sintering of Polycaprolactone Bone Tissue Engineering Scaffolds

Published online by Cambridge University Press:  01 February 2011

Brock Partee ,
Scott J. Hollister  and
Suman Das
Brock Partee
Affiliation:
Mechanical, University of Michigan Ann Arbor, MI 48109-2125, U.S.A.
Scott J. Hollister
Affiliation:
Mechanical, University of Michigan Ann Arbor, MI 48109-2125, U.S.A. Biomedical Engineering Departments, University of Michigan Ann Arbor, MI 48109-2125, U.S.A.
Suman Das
Affiliation:
Mechanical, University of Michigan Ann Arbor, MI 48109-2125, U.S.A.
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Abstract

Present tissue engineering practice requires porous, bioresorbable scaffolds to serve as temporary 3D templates to guide cell attachment, differentiation, and proliferation. Recent research suggests that scaffold material and internal architecture significantly influence regenerate tissue structure and function. However, lack of versatile biomaterials processing methods have slowed progress towards fully testing these findings. Our research investigates using selective laser sintering (SLS) to fabricate bone tissue engineering scaffolds. Using SLS, we have fabricated polycaprolactone (PCL) and polycaprolactone/tri-calcium phosphate composite scaffolds. We report on scaffold design and fabrication, mechanical property measurements, and structural characterization via optical microscopy and micro-computed tomography.

Information

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 845: Symposium AA – Nanoscale Materials Science in Biology and Medicine , 2004 , AA9.9
Copyright
Copyright © Materials Research Society 2005

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References

REFERENCES

1. U.S. Scientific Registry for Organ Transplantation and the Organ Procurement and Transplantation Network. Annual Report. Richmond, VA: UNOS, 1990.Google Scholar
2. Langer, R. and Vacanti, J.. “Tissue Engineering.” Science. 260, 920–926 (1993).Google Scholar
3. Griffith, Linda, and Naughton, Gail. “Tissue Engineering—Current Challenges and Expanding Opportunities.” Science. 295, 1009–1014 (2002).Google Scholar
4. Yang, S., Kah-Fai, L., Zhaohui, D. and Chee-Kai, C.. “The Design of Scaffolds for Use in Tissue Engineering. Part I: Traditional Factors.” Tissue Engineering. 7, 679–689 (2001).Google Scholar
5. Bruder, S.P., Kraus, K.H., Goldberg, V.M., and Kadiyala, S.. “Critical-Sized Canine Segmental Femoral Defects are Healed by Autologus Mesenchymal Stem Cell Therapy.” Transactions of the 44th Annual Meeting of the Orthopedic Research Society. 147 (1998).Google Scholar
6. Mikos, A.G., Sarakinos, G., Lyman, M.D., Ingber, D.E., Vacanti, J.P., Langer, R.. “Prevascularization of porous biodegradable polymer.” Biotechnol. Bioeng. 42, 716–723 (1993).Google Scholar
7. Hollister, S.J., Maddox, R.D., Taboas, J.M.. “Optimal Design and Fabrication of Scaffolds to Mimic Tissue Properties and Satisfy Biological Constraints.” Biomaterials. 23, 4095–4103 (2002).Google Scholar
8. Deckard, C.R., “Selective Laser Sintering.”, Ph.D. thesis, University of Texas at Austin, 1988.Google Scholar
9. Properties & Processing of CAPA® Thermoplastics. Solvay Caprolactones. Issue 1. (April 2001).Google Scholar
9. Goulet, R.W., Goldstein, S.A., Ciarelli, M.J., Kuhn, J.L., Brown, M.B., and Feldkamp, L.A.. “The relationship between the structural and orthogonal compressive properties of trabecular bone.” J Biomechanics. 27, 375–389 (1994).Google Scholar