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The Role of Fibrinogen in Platelet Interaction with Methacrylate Polymers

Published online by Cambridge University Press:  26 February 2011

Jack N. Lindon ,
Eiichi Shiba ,
Leslie Kushner  and
Edwin W. Salzman
Jack N. Lindon
Affiliation:
Beth Israel Hospital and Harvard Medical School, Boston, MA
Eiichi Shiba
Affiliation:
Beth Israel Hospital and Harvard Medical School, Boston, MA
Leslie Kushner
Affiliation:
Beth Israel Hospital and Harvard Medical School, Boston, MA
Edwin W. Salzman
Affiliation:
Beth Israel Hospital and Harvard Medical School, Boston, MA
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Abstract

When blood comes in contact with a foreign surface, protein adsorption occurs within seconds and precedes the arrival of blood cells. Since a layer of plasma proteins is laid down on any surface in contact with blood before the platelets arrive, differences in platelet reactivity with different surfaces must result from variations in the nature of the protein-surface interactions. These interactions may vary in terms of which proteins bind to the surfaces, the amounts bound, and the various changes in protein conformation induced by surface contact.

Information

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 661
Copyright
Copyright © Materials Research Society 1988

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