Hostname: page-component-745bb68f8f-mzp66 Total loading time: 0 Render date: 2025-02-05T06:10:56.030Z Has data issue: false hasContentIssue false
  • English
  • Français

Rheology of Sodium Hyaluronate Solutions and Relevance to their Use as Medical Implants

Published online by Cambridge University Press:  26 February 2011

Dale P. Devore ,
Sandra A. Loftus  and
B. S. MedChem
Dale P. Devore
Affiliation:
Products, Inc., Acton, MA 01720
Sandra A. Loftus
Affiliation:
Products, Inc., Acton, MA 01720
B. S. MedChem
Affiliation:
Products, Inc., Acton, MA 01720
Get access

Extract

Hyaluronic acid is a high molecular weight, linear polysaccharide composed of repeating subunits of glucuronic acid and N-acetylglucosamine. The structure is shown in figure 1. In vertebrates, the polymer is widely distributed through all connective tissue and has been implicated in cell-cell interaction, cell matrix adhesion, cell mobility and extracellular matrix organization (1,2). NaHA is an important tissue lubricant (3,4) and has been shown to exert a facilitating influence on wound repair (5).

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 455
Copyright
Copyright © Materials Research Society 1988

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Toole, B.R., Goldberg, R.L., Chi-Russo, G., Underhill, C.B., and Orkin, R.W., in The Role of Extracellular Matrix in Development, edited by Trelstad, P.L. (Alan Liss, Inc., New York, 1984) pp. 43–66.Google Scholar
2. Toole, B.R., in Cell Biology of the Extracellular Matrix, edited by Nay, E.D. (Plenum Press, New York, 1981) pp.2259–294.Google Scholar
3. Swann, D.A., Radin, E.L. and Nazimiec, M., Am.Rheum.Dis. 33, 318 (1974).Google Scholar
4. Swann, D.A., in The Joints and Synovial Fluid, edited by Sokoloff, L. (Academic Press, New York, 1978) pp.407–435.Google Scholar
5. Abatangelo, G., Martelli, M., and Vecchia, P., J.Surg.Res. 35, 410 (1983).CrossRefGoogle Scholar
6. Dische, Z., J.Biol.Chem 167, 189 (1947).Google Scholar
7. Gregory, J.D., Arch. Biochem. Biophys. 89, 157, (1960).Google Scholar
8. Bitter, T. and Muir, H.M., Anal.Biochem. 4, 330 (1962)Google Scholar
9. Laurent, T.C., Ryan, M., and Pietruszkiewicz, A., Biochem.Biophys.Acta 42, 476 (1960)Google Scholar
10. Gibbs, D.A., Merrill, E.W., and Smith, K.A., Biopolymers 6, 771 (1968)CrossRefGoogle Scholar
11. Balazs, E.A. and Denlinger, J.L., Equine Veterinary Science 5, 217 (1985)Google Scholar