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Quantitative Investigations of Nanoscale Elasticity of Nanofibrillar Matrices

Published online by Cambridge University Press:  31 January 2011

Volkan M Tiryaki ,
Adeel Ahmed Khan ,
Alicia Pastor ,
Raed A Alduhaileb ,
Roberto Delgado-Rivera ,
Ijaz Ahmed ,
Sally A Meiners  and
Virginia M Ayres
Volkan M Tiryaki
Affiliation:
tiryakiv@msu.edu, Michigan State University, College of Engineering, East Lansing, Michigan, United States
Adeel Ahmed Khan
Affiliation:
adeel_net@yahoo.com, Western Michigan University, College of Engineering and Applied Sciences, Kalamazoo, Michigan, United States
Alicia Pastor
Affiliation:
pastorle@msu.edu, Michigan State University, Center for Advanced Microscopy, East Lansing, Michigan, United States
Raed A Alduhaileb
Affiliation:
alduhail@msu.edu, Michigan State University, College of Engineering, East Lansing, Michigan, United States
Roberto Delgado-Rivera
Affiliation:
robertde@eden.rutgers.edu, Rutgers University, The State University of New Jersey, Piscataway, New Jersey, United States
Ijaz Ahmed
Affiliation:
ahmedij@umdnj.edu, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, United States
Sally A Meiners
Affiliation:
meiners@umdnj.edu, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, United States
Virginia M Ayres
Affiliation:
ayresv@msu.edu, Michigan State University, College of Engineering, East Lansing, Michigan, United States
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Abstract

Recent research indicates that nanophysical properties as well as biochemical cues can influence cellular re-colonization of a tissue scaffold. It has also been shown nanoscale elasticity can strongly influence cellular responses. In the present work, quantitative investigations of the elasticity of a nanofibrillar matrix scaffold that has demonstrated promise for spinal cord injury repair are compared with complementary transmission electron microscopy investigations, performed to assess nanofiber internal structures. Interpretive model improvements are identified and discussed.

Keywords

elastic propertiestissuetransmission electron microscopy (TEM)

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