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Nanoporous Alumina Coatings for Medical Implants and Stents - Radiotherapy, Drug Delivery, Biological Compatibility

Published online by Cambridge University Press:  21 February 2011

T. Sawitowski ,
W. Brandau ,
A. Fischer ,
A. Heilmann  and
G. Schmid
T. Sawitowski
Affiliation:
Institut für Werkstofftechnik, University of Essen, Universitätsstr. 5-7, 45130 Essen, Germany
W. Brandau
Affiliation:
Institut für Nuklearchemie und Radiopharmacie, University of Essen, 45122 Essen, Germany
A. Fischer
Affiliation:
Institut für Anorganische Chemie, University of Essen, Universitätsstr. 5-7, 45130 Essen, Germany Institut für Werkstofftechnik, University of Essen, Universitätsstr. 5-7, 45130 Essen, Germany
A. Heilmann
Affiliation:
Fraunhofer Institut für Werkstoffmechanik, Heideallee 19, D-06210 Halle, Germany
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Abstract

The body implant interaction is strongly affected by the implant surface structure and chemistry [1,2]. Thus by applying a nanoporous coating to metallic implants the implant surface can be adjusted to different needs. Compared to biological molecules the size of the pores is so small (between 5 nm and 250 nm) that the cellular response to this surface modification is not affected by the structure itself. Nevertheless by loading the pores with bioactive molecules it is possible to achieve a new kind of active implants surfaces for soft and hard tissue implants. With this coating it is possible to irreversibly bind radioactive isotopes like 99mTc, 186/188Re, 103Pd, and many more for local radiotherapy onto soft tissue implants like stents or seeds.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 581: Symposium F – Nanophase & Nanocomposite Materials II , 1999 , 523
Copyright
Copyright © Materials Research Society 2000

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References

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