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Human Osteoblast Expression of Osteonectin on Different Charged Substrata

Published online by Cambridge University Press:  15 February 2011

M. Russell ,
L. Zou ,
H. Keeping ,
M. G. Ehrlich  and
W. R. Walsh
M. Russell
Affiliation:
Biomechanics Laboratory, Department of Orthopaedics, Rhode Island Hospital, Brown University School of Medicine.
L. Zou
Affiliation:
Biomechanics Laboratory, Department of Orthopaedics, Rhode Island Hospital, Brown University School of Medicine.
H. Keeping
Affiliation:
Biomechanics Laboratory, Department of Orthopaedics, Rhode Island Hospital, Brown University School of Medicine.
M. G. Ehrlich
Affiliation:
Biomechanics Laboratory, Department of Orthopaedics, Rhode Island Hospital, Brown University School of Medicine.
W. R. Walsh
Affiliation:
Biomechanics Laboratory, Department of Orthopaedics, Rhode Island Hospital, Brown University School of Medicine. Division of Engineering, Brown University, Providence, RI.
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Extract

Cellular interactions at the interface between bone and a prosthetic device plays an important role in total joint reconstruction success or failure. Aseptic loosening is a typical long-term complication encountered due to a failure at this interface. A number of factors have been shown to influence cell mitogenic and morphological behavior including load and stability [1] surface topography and surface chemistry [2]. The selection of suitable surface coatings on a prosthetic device would be facilitated if the nature of the interaction of bone cells to surface could be predicted from appropriate behavior of cells in tissue culture [3]. Molecular biology techniques now enable investigators to study cell-substrate interactions and gene expression at the mRNA level.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 331: Symposium T – Biomaterials for Drug and Cell Delivery , 1993 , 133
Copyright
Copyright © Materials Research Society 1994

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References

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