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From BioMEMS to Bionanotechnology: Integrated BioChips for the Detection of Cells and Microorganisms

Published online by Cambridge University Press:  15 February 2011

R. Bashir ,
D. Akin ,
R. Gómez ,
H. Li ,
W.J. Chang  and
A. Gupta
R. Bashir
Affiliation:
School of Electrical and Computer Engineering Department of Biomedical Engineering, Purdue University, W. Lafayette, IN. 47907
D. Akin
Affiliation:
School of Electrical and Computer Engineering
R. Gómez
Affiliation:
School of Electrical and Computer Engineering
H. Li
Affiliation:
School of Electrical and Computer Engineering
W.J. Chang
Affiliation:
School of Electrical and Computer Engineering
A. Gupta
Affiliation:
School of Electrical and Computer Engineering
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Abstract

This paper reviews the interdisciplinary work performed in our group in recent years to develop micro-integrated devices to characterize biological entities. We present the use of electrical and mechanically based phenomena to perform characterization and various functions needed for integrated biochips. One sub-system takes advantage of the dielectrophoretic effect to sort and concentrate cells within a micro-fluidic biochip. Another sub-system measures impedance changes produced by the metabolic activity of cells to determine their viability. A third sub-system is used to detect the mass of bacteria as they bind to micro-mechanical silicon cantilevers. These devices with an electronic signal output can be very useful in producing practical systems for rapid detection and characterization of cells for a wide variety of applications in the food safety and health diagnostics industries.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 773: Symposium N – Biomicroelectromechanical Systems (BioMEMS) , 2003 , N9.1
Copyright
Copyright © Materials Research Society 2003

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