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Effect of a Moderate Blood Exchange with Fluosol-Da 20% on the Disposition of Digoxin in the Dog

Published online by Cambridge University Press:  26 February 2011

John F. Hoke  and
William R. Ravis
John F. Hoke
Affiliation:
Auburn University, Dept. of Pharmacal Sciences, School of Pharmacy, Auburn, Alabama 36849
William R. Ravis
Affiliation:
Auburn University, Dept. of Pharmacal Sciences, School of Pharmacy, Auburn, Alabama 36849
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Abstract

The effect of a perfluorochemical blood substitute (Fluosol-DA 20%) on the disposition kinetics of digoxin in the dog was studied. An intravenous dose of digoxin was administered at either 0.25 or 24 hours following a 30% blood exchange with the dog's own blood (SHAM group) or Fluosol-DA (treatment group). A significant change in the initial volume of distribution and mean residence time in the serum was noted when digoxin was administered 0.25 hours after the Fluosol-DA blood exchange. This volume of distribution change was not observed when digoxin was administered 24 hours after the Fluosol-DA blood exchange. No change in the t1/2, total body clearance, or volume of distribution at steady-state was observed in any of the treatments. No change in the partitioning of digoxin in the blood was noted following Fluosol-DA administration.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 141
Copyright
Copyright © Materials Research Society 1988

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