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Cationic Lipid Modulates Phospholipid Adsorption on Silica

Published online by Cambridge University Press:  01 February 2011

Sérgio P. Moura  and
Ana Maria Carmona-Ribeiro
Sérgio P. Moura
Affiliation:
Instituto de Química-Universidade de Sao Paulo, Dept Bioquímica, Brazil
Ana Maria Carmona-Ribeiro
Affiliation:
amcr@usp.br, Instituto de Química-Universidade de Sao Paulo, Dept Bioquímica, Brazil
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Abstract

At 2 % cationic lipid and 98 % phospholipid, pH 6.3, in pure water, high affinity adsorption isotherms with limiting adsorption indicative of one bilayer deposition on each silica particle were obtained whereas for the other molar proportions tested, limiting lipid adsorption was either above or below the level expected for bilayer deposition. This suggested a modulating role for cationic lipid allowing control of total amount of lipid adsorbed on silica. Silica sedimentation documented from photographs was almost absent over a range of lipid concentrations where bilayer deposition was achieved.

Keywords

adsorptionbiomimetic (assembly)particulate
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 900: Symposium O – Nanoparticles and Nanostructures in Sensors and Catalysis , 2005 , 0900-O03-35
Copyright
Copyright © Materials Research Society 2006

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