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3D Composites Based on Hydroxyapatite-Chitosan-Polysiloxane as a Biomimetic Scaffold Materials

Published online by Cambridge University Press:  17 March 2011

Andrónico Neira-Carrillo ,
José Ignacio Arias ,
M. Soledad Fernández ,
Ranjith Krishna Pai ,
C Claudia Quilodrán  and
José L Arias
Andrónico Neira-Carrillo
Affiliation:
CIMAT and Faculty of Veterinary and Animal Science, University of Chile, Santa Rosa 11735, La Pintana, Casilla 2 Correo 15, Santiago, 2-15, Chile
José Ignacio Arias
Affiliation:
CIMAT and Faculty of Veterinary and Animal Science, University of Chile, Santa Rosa 11735, La Pintana, Casilla 2 Correo 15, Santiago, 2-15, Chile
M. Soledad Fernández
Affiliation:
CIMAT and Faculty of Veterinary and Animal Science, University of Chile, Santa Rosa 11735, La Pintana, Casilla 2 Correo 15, Santiago, 2-15, Chile
Ranjith Krishna Pai
Affiliation:
CIMAT and Faculty of Veterinary and Animal Science, University of Chile, Santa Rosa 11735, La Pintana, Casilla 2 Correo 15, Santiago, 2-15, Chile
C Claudia Quilodrán
Affiliation:
CIMAT and Faculty of Veterinary and Animal Science, University of Chile, Santa Rosa 11735, La Pintana, Casilla 2 Correo 15, Santiago, 2-15, Chile
José L Arias
Affiliation:
CIMAT and Faculty of Veterinary and Animal Science, University of Chile, Santa Rosa 11735, La Pintana, Casilla 2 Correo 15, Santiago, 2-15, Chile
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Abstract

Three-dimensional (3D) composites of hydroxyapatite, phosphorylated and/or nonphosphorylated chitosan and sulphonated methylsiloxane polymer (HA/P-CHI: CHI/ S-MSP) were prepared by solid-liquid phase separation and solvent sublimation method. The HA, P-CHI and S-MSP were synthesized by chemical continuous wet-calcination, phosphorylation reaction and hydrosilylation-sulphonation reactions, respectively. 3D composites were analyzed by scanning electron microscopy (SEM). Swelling ability, stability and formation of HA particles on the composites immersed in simulated body fluid (SBF) were analyzed. Osteoblasts showed high viability when cultured on composite scaffolds. 3D composites were not degraded after 8 weeks of subcutaneous implantation in rats.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1007: Symposium S – Organic/Inorganic Hybrid Materials-2007 , 2007 , 1007-S04-49
Copyright
Copyright © Materials Research Society 2007

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