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Take a deep breath and digest the material: organoids and biomaterials of the respiratory and digestive systems

Published online by Cambridge University Press:  14 August 2017

Briana R. Dye ,
Tadas Kasputis ,
Jason R. Spence  and
Lonnie D. Shea
Briana R. Dye
Affiliation:
Biomedical Engineering, University of Michigan Biomedical Engineering, Ann Arbor, Michigan 48109, USA
Tadas Kasputis
Affiliation:
Biomedical Engineering, University of Michigan Biomedical Engineering, Ann Arbor, Michigan 48109, USA
Jason R. Spence
Affiliation:
Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA Department of Cell and Developmental Biology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA Center of Organogenesis, Michigan Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
Lonnie D. Shea*
Affiliation:
Biomedical Engineering, University of Michigan Biomedical Engineering, Ann Arbor, Michigan 48109, USA
*
Address all correspondence to Lonnie D. Shea at ldshea@umich.edu
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Abstract

Human organoid models recapitulate many aspects of the complex composition and function of native organs. One of the main challenges in developing these models is the growth and maintenance of three-dimensional tissue structures and proper cellular organization that enable function. Biomaterials play an important role by providing a defined and tunable three-dimensional environment that is required for complex cellular organization and organoid growth in vitro or in vivo. This review summarizes organoids of the respiratory and digestive system, and the use of biomaterials to improve upon these model systems.

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Type
Biomaterials for 3D Cell Biology Prospective Article
Information
MRS Communications , Volume 7 , Issue 3 , September 2017 , pp. 502 - 514
Copyright
Copyright © Materials Research Society 2017 

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