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Polymeric scaffolds for three-dimensional culture of nerve cells: a model of peripheral nerve regeneration

Published online by Cambridge University Press:  03 October 2017

Radamés Ayala-Caminero ,
Luis Pinzón-Herrera ,
Carol A. Rivera Martinez  and
Jorge Almodovar
Radamés Ayala-Caminero
Affiliation:
Bioengineering Program, University of Puerto Rico Mayaguez, Call Box 9000, Mayagüez, Puerto Rico 00681-9000, USA
Luis Pinzón-Herrera
Affiliation:
Department of Chemical Engineering, University of Puerto Rico Mayagüez, Call Box 9000, Mayaguez, Puerto Rico 00681-9000, USA
Carol A. Rivera Martinez
Affiliation:
Bioengineering Program, University of Puerto Rico Mayaguez, Call Box 9000, Mayagüez, Puerto Rico 00681-9000, USA
Jorge Almodovar*
Affiliation:
Bioengineering Program, University of Puerto Rico Mayaguez, Call Box 9000, Mayagüez, Puerto Rico 00681-9000, USA Department of Chemical Engineering, University of Puerto Rico Mayagüez, Call Box 9000, Mayaguez, Puerto Rico 00681-9000, USA
*
Address all correspondence to J. Almodovar at jorge.almodovar1@upr.edu
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Abstract

Understanding peripheral nerve repair requires the evaluation of three-dimensional (3D) structures that serve as platforms for 3D cell culture. Multiple platforms for 3D cell culture have been developed, mimicking peripheral nerve growth and function, in order to study tissue repair or diseases. To recreate an appropriate 3D environment for peripheral nerve cells, key factors are to be considered, including selection of cells, polymeric biomaterials to be used, and fabrication techniques to shape and form the 3D scaffolds for cellular culture. This review focuses on polymeric 3D platforms used for the development of 3D peripheral nerve cell cultures.

Type
Biomaterials for 3D Cell Biology Prospective Articles
Information
MRS Communications , Volume 7 , Issue 3 , September 2017 , pp. 391 - 415
Copyright
Copyright © Materials Research Society 2017 

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