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Monitoring the adaptive cell response to hyperosmotic stress by organic devices

Published online by Cambridge University Press:  08 May 2017

Pasquale D'Angelo ,
Giuseppe Tarabella ,
Agostino Romeo ,
Angela Giodice ,
Simone Marasso ,
Matteo Cocuzza ,
Francesca Ravanetti ,
Antonio Cacchioli ,
Pier Giorgio Petronini  and
Salvatore Iannotta
Pasquale D'Angelo*
Affiliation:
Institute of Materials for Electronics and Magnetism, National Research Council, P.co Area delle Scienze 37/A, 43124 Parma, Italy
Giuseppe Tarabella
Affiliation:
Institute of Materials for Electronics and Magnetism, National Research Council, P.co Area delle Scienze 37/A, 43124 Parma, Italy
Agostino Romeo
Affiliation:
Institute of Materials for Electronics and Magnetism, National Research Council, P.co Area delle Scienze 37/A, 43124 Parma, Italy
Angela Giodice
Affiliation:
Institute of Materials for Electronics and Magnetism, National Research Council, P.co Area delle Scienze 37/A, 43124 Parma, Italy
Simone Marasso
Affiliation:
Institute of Materials for Electronics and Magnetism, National Research Council, P.co Area delle Scienze 37/A, 43124 Parma, Italy Department of Applied Science and Technology, Politecnico di Torino, C.so Duca degli Abruzzi 24, 10129 Torino, Italy
Matteo Cocuzza
Affiliation:
Institute of Materials for Electronics and Magnetism, National Research Council, P.co Area delle Scienze 37/A, 43124 Parma, Italy Department of Applied Science and Technology, Politecnico di Torino, C.so Duca degli Abruzzi 24, 10129 Torino, Italy
Francesca Ravanetti
Affiliation:
Department of Veterinary Sciences, University of Parma, Via del Taglio, 10, 43126 Parma, Italy
Antonio Cacchioli
Affiliation:
Department of Veterinary Sciences, University of Parma, Via del Taglio, 10, 43126 Parma, Italy
Pier Giorgio Petronini
Affiliation:
Unit of Experimental Oncology, Department of Clinical and Experimental Medicine, University of Parma, Plesso Biotecnologico Integrato, Via Volturno, 39—Palazzina D 10 piano, 43125 Parma, Italy
Salvatore Iannotta
Affiliation:
Institute of Materials for Electronics and Magnetism, National Research Council, P.co Area delle Scienze 37/A, 43124 Parma, Italy
*
Address all correspondence to Pasquale D'Angelo at pasquale.dangelo@imem.cnr.it
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Abstract

Cellular activity upon osmotic stress is related to the occurrence of several disease conditions. The real-time monitoring of the cell response to this kind of stress can give insight into the comprehension of mechanisms involved in cellular shrinkage. Currently the dynamics of the osmotic stress is studied using dedicated and tricky methodologies, not suited to the in vivo testing. We show that a disposable electronic device is very effective for studying the early stage of the osmotic stress induced on human lung adenocarcinoma cells, A549, by a hyperosmotic environment. Our findings corroborate the experimental results obtained by a standard complementary analysis.

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Type
Research Letters
Information
MRS Communications , Volume 7 , Issue 2 , June 2017 , pp. 229 - 235
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Copyright
Copyright © Materials Research Society 2017 

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Footnotes

*

Current address: CAMLIN Italy Srl - Strada Budellungo 2, 43123 Parma, Italy.

**

Current address: Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac, 10-12, 08028 Barcelona, Spain.

†

Current address: Institute for Bioengineering of Catalonia (IBEC), C. Baldiri Reixac, 10-12, 08028 Barcelona, Spain.

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