Hostname: page-component-5447f9dfdb-97xxw Total loading time: 0 Render date: 2025-07-29T06:36:24.066Z Has data issue: false hasContentIssue false
  • English
  • Français

Biocompatibility of a novel heat-treated and ceramic-coated magnesium alloy (Mg–1.2Zn–0.5Ca–0.5Mn) for resorbable skeletal fixation devices

Published online by Cambridge University Press:  10 August 2020

Agnieszka Chmielewska ,
Taylor MacDonald ,
Hamdy Ibrahim ,
Tim McManus ,
Jan Lammel Lindemann Open the ORCID record for Jan Lammel Lindemann [Opens in a new window] ,
Patrick Smith ,
Lihan Rong ,
Alan Luo ,
Rigoberto Advincula  and
Wojciech Swieszkowski
...Show all authors
Agnieszka Chmielewska
Affiliation:
Department of Plastic and Reconstructive Surgery, The Ohio State University, Columbus, OH43210, USA Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw02-507, Poland
Taylor MacDonald
Affiliation:
Department of Plastic and Reconstructive Surgery, The Ohio State University, Columbus, OH43210, USA
Hamdy Ibrahim
Affiliation:
Department of Mechanical Engineering, University of Tennessee – Chattanooga, Chattanooga, TN37403, USA
Tim McManus
Affiliation:
Department of Plastic and Reconstructive Surgery, The Ohio State University, Columbus, OH43210, USA
Jan Lammel Lindemann
Affiliation:
Department of Plastic and Reconstructive Surgery, The Ohio State University, Columbus, OH43210, USA Escuela de Ingenieria y Ciencias, Tecnologico de Monterrey, Monterrey, NL64849, Mexico Laboratorio Nacional de Manufactura Aditiva y Digital (MADiT), Apodaca, NL66629, Mexico
Patrick Smith
Affiliation:
Department of Plastic and Reconstructive Surgery, The Ohio State University, Columbus, OH43210, USA
Lihan Rong
Affiliation:
Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH44106, USA
Alan Luo
Affiliation:
Department of Materials Science and Engineering, The Ohio State University, Columbus, OH43210, USA
Rigoberto Advincula
Affiliation:
Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH44106, USA
Wojciech Swieszkowski
Affiliation:
Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw02-507, Poland
Mohammad Elahinia
Affiliation:
Department of Mechanical, Industrial and Manufacturing Engineering, University of Toledo, Toledo, OH43606, USA
David Dean*
Affiliation:
Department of Plastic and Reconstructive Surgery, The Ohio State University, Columbus, OH43210, USA Department of Materials Science and Engineering, The Ohio State University, Columbus, OH43210, USA
*
Address all correspondence to David Dean at David.Dean@osumc.edu
Get access

Abstract

Our recent exploration into the use of biodegradable metals and surface treatments resulting in sufficient strength for skeletal reconstruction applications has led to the need to test these devices’ cytotoxicity. More specifically, our group has developed a resorbable magnesium alloy, Mg–1.2Zn–0.5Ca–0.5Mn, that can be strengthened by heat treatment and coated with a ceramic layer offering time-certain resorption of a medical device. This in vitro study shows that these treatments do not result in cytotoxicity. Both heat-treated (HT) and HT + ceramic-coated (sol–gel) coupons demonstrated more than 70% viability. Thus, these processing steps are likely to be useful in producing biocompatible, resorbable implants that incorporate our Mg–1.2Zn–0.5Ca–0.5Mn alloy.

Information

Type
Research Letters
Information
MRS Communications , Volume 10 , Issue 3 , September 2020 , pp. 467 - 474
Check for updates
Copyright
Copyright © Materials Research Society, 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

*

This author was an editor of this journal during the review and decision stage. For the MRC policy on review and publication of manuscripts authored by editors, please refer to http://www.mrs.org/editor-manuscripts/.

References

Buddy, R., Lemons, J., Hoffman, A., and Schoen, F. (eds.): Biomaterials Science. 3rd ed, 2012. https://www.elsevier.com/books/biomaterials-science/ratner/978-0-08-087780-8 (accessed December 11, 2018).Google Scholar
Wu, S., Liu, X., Yeung, K.W.K., Guo, H., Li, P., Hu, T., Chung, C.Y., and Chu, P.K.: Surface nano-architectures and their effects on the mechanical properties and corrosion behavior of Ti-based orthopedic implants. Surf. Coat. Technol. 233, 13 (2013).CrossRefGoogle Scholar
Farraro, K.F., Kim, K.E., Woo, S.L., Flowers, J.R., and Mccullough, M.B.: Revolutionizing orthopaedic biomaterials: the potential of biodegradable and bioresorbable magnesium-based materials for functional tissue engineering. J. Biomech. 47, 1979 (2014).CrossRefGoogle ScholarPubMed
Hong, D., Saha, P., Chou, D., Lee, B., Collins, B.E., Tan, Z., Dong, Z., and Kumta, P.N.: In vitro degradation and cytotoxicity response of Mg–4% Zn–0.5% Zr (ZK40) alloy as a potential biodegradable material. Acta Biomater. 9, 8534 (2013).CrossRefGoogle ScholarPubMed
Galante, J., Lemons, J., Spector, M., Wilson, P.D., and Wright, T.M.: The biologic effects of implant materials. J. Orthop. Res. 9, 760 (1991).CrossRefGoogle ScholarPubMed
Zheng, Y.F., Gu, X.N., and Witte, F.: Biodegradable metals. Mater. Sci. Eng. 77, 1 (2014).CrossRefGoogle Scholar
Lester, G.E. and Buckley, J.: Stress shielding effect of rigid internal fixation plates on mandibular bone grafts. Res. Dev. 18, 307 (1989).Google Scholar
Manivasagam, G., Suwas, S., Manivasagam, G., and Suwas, S.: Biodegradable Mg and Mg based alloys for biomedical implants. Mater. Sci. Technol. 0836, 515 (2014).CrossRefGoogle Scholar
Witte, F.: The history of biodegradable magnesium implants: a review. Acta Biomater. 6, 1680 (2010).CrossRefGoogle ScholarPubMed
Gill, P., Munroe, N., Dua, R., and Ramaswamy, S.: Corrosion and biocompatibility assessment of magnesium alloys. J. Biomater. Nanobiotechnol. 3, 10 (2012).CrossRefGoogle Scholar
Witte, F., Kaese, V., Haferkamp, H., Switzer, E., and Meyer-Lindenberg, A.: In vivo corrosion of four magnesium alloys and the associated bone response. Biomaterials 26, 3557 (2005).CrossRefGoogle ScholarPubMed
Pogorielov, M., Husak, E., Solodivnik, A., and Zhdanov, S.: Magnesium-based biodegradable alloys: degradation, application, and alloying elements. Interv. Med. Appl. Sci. 9, 27 (2017).Google ScholarPubMed
Wu, G., Xu, R., Feng, K., Wu, S., Wu, Z., Sun, G., Zheng, G., Li, G., and Chu, P.K.: Retardation of surface corrosion of biodegradable magnesium-based materials by aluminum ion implantation. Appl. Surf. Sci. 258, 7651 (2012).CrossRefGoogle Scholar
Bakhsheshi-Rad, H.R., Idris, M.H., Abdul-Kadir, M.R., Ourdjini, A., Medraj, M., and Daroonparvar, M.: Mechanical and bio-corrosion properties of quaternary Mg–Ca–Mn–Zn alloys compared with binary Mg–Ca alloys. Mater. Des. 53, 283 (2014).CrossRefGoogle Scholar
Berglund, I.S., Brar, H.S., Dolgova, N., Acharya, A.P., Benjamin, G., Sarntinoranont, M., and Manuel, M.V.: Synthesis and characterization of Mg-Ca-Sr alloys for biodegradable orthopedic implant applications. J. Biomed. Mater. Res. Part B. 100B, 1524–1534 (2012).CrossRefGoogle Scholar
Zhao, D., Witte, F., Lu, F., Wang, J., Li, J., and Qin, L.: Current status on clinical applications of magnesium-based orthopaedic implants: a review from clinical translational perspective. Biomaterials 112, 287 (2017).CrossRefGoogle ScholarPubMed
Ibrahim, H., Klarner, A.D., Poorganji, B., Dean, D., Luo, A.A., and Elahinia, M.: Microstructural, mechanical and corrosion characteristics of heat-treated Mg-1.2Zn-0.5Ca (wt%) alloy for use as resorbable bone fixation material. J. Mech. Behav. Biomed. Mater. 69, 203 (2017).CrossRefGoogle ScholarPubMed
Ibrahim, H. and Elahinia, M.: Fabrication and characterization of a biocompatible coating formed on a heat-treated magnesium alloy using micro-arc oxidation. MSEC2017-3080 1. Proceedings of the ASME 2017 12th International Manufacturing Science and Engineering Conference MSEC2017 June 4-8, 2017, Los Angeles, CA, USA19 (2017).Google Scholar
Ibrahim, H., Dean, D., Klarner, A.D., and Luo, A.A.: The effect of heat-treatment on mechanical, microstructural, and corrosion characteristics of a magnesium alloy with potential application in resorbable bone fixation hardware. MSEC2016-8822 1. Proceedings of the ASME 2016 International Manufacturing Science and Engineering Conference MSEC2016 June 27-July 1, 2016, Blacksburg, Virginia, USA32 (2017).Google Scholar
Asri, R.I.M., Harun, W.S.W., Samykano, M., Lah, N.A.C., Ghani, S.A.C., Tarlochan, F., and Raza, M.R.: Corrosion and surface modification on biocompatible metals: a review. Mater. Sci. Eng. C 77, 1261 (2017).CrossRefGoogle ScholarPubMed
Asri, R.I.M., Harun, W.S.W., Hassan, M.A., Ghani, S.A.C., and Buyong, Z.: A review of hydroxyapatite-based coating techniques: sol–gel and electrochemical depositions on biocompatible metals. J. Mech. Behav. Biomed. Mater. 57, 95 (2016).CrossRefGoogle ScholarPubMed
Harun, W.S.W., Asri, R.I.M., Alias, J., Zulki, F.H., Kadirgama, K., Ghani, S.A.C., and Shari, J.H.M.: A comprehensive review of hydroxyapatite-based coatings adhesion on metallic biomaterials. Ceram. Int. 44, 1250 (2018).CrossRefGoogle Scholar
Roy, A., Singh, S.S., Kanchan, M., Lee, B., Ohodnicki, J., and Kumta, P.N.: Novel sol–gel derived calcium phosphate coatings on Mg4Y alloy. Mater. Sci. Eng. B 176, 1679 (2011).CrossRefGoogle Scholar
Ibrahim, H., Esfahani, S.N., Poorganji, B., Dean, D., and Elahinia, M.: Resorbable bone fixation alloys, forming, and post-fabrication treatments. Mater. Sci. Eng. C 70, 870 (2017).CrossRefGoogle ScholarPubMed
Ibrahim, H., Dehghanghadikolaei, A., Advincula, R., Dean, D., Luo, A., and Elahinia, M.: Ceramic coating for delayed degradation of Mg-1.2Zn-0.5Ca-0.5Mn bone fixation and instrumentation. Thin Solid Films 687, 137456 (2019).CrossRefGoogle Scholar
Wang, J., Witte, F., Xi, T., Zheng, Y., Yang, K., Yang, Y., and Zhao, D.: Recommendation for modifying current cytotoxicity testing standards for biodegradable magnesium-based materials. Acta Biomater. 21, 237 (2015).CrossRefGoogle ScholarPubMed
Fischer, J., Pröfrock, D., Hort, N., Willumeit, R., and Feyerabend, F.: Reprint of: Improved cytotoxicity testing of magnesium materials. Mater. Sci. Eng. B 176, 1773 (2011).CrossRefGoogle Scholar
Keim, S., Brunner, J.G., Fabry, B., and Virtanen, S.: Control of magnesium corrosion and biocompatibility with biomimetic coatings. J. Biomed. Mater. Res. B Appl. Biomater. 98B(1), 84 (2010).Google Scholar
Li, Z., Gu, X., Lou, S., and Zheng, Y.: The development of binary Mg-Ca alloys for use as biodegradable materials within bone. Biomaterials 29, 1329 (2008).CrossRefGoogle ScholarPubMed
ISO Standard: No T4:00-17:00, ISO10993-5:2009, ISO.Google Scholar
Ibrahim, H., Luo, A., Dean, D., and Elahinia, M.: Effect of Zn content and aging temperature on the in-vitro properties of heat-treated and Ca/P ceramic-coated Mg-0.5%Ca-x%Zn alloys. Mater. Sci. Eng. C 103, 109700 (2019).CrossRefGoogle ScholarPubMed
Agarwal, S., Curtin, J., Duffy, B., and Jaiswal, S.: Biodegradable magnesium alloys for orthopaedic applications: a review on corrosion, biocompatibility and surface modifications. Mater. Sci. Eng. C 68, 948 (2016).CrossRefGoogle ScholarPubMed
Seal, C.K. and Hodgson, M.: Biodegradable surgical implants based on magnesium alloys – a review of current research. No. July 2016. Article in IOP Conference Series Materials Science and Engineering August 2009 (2009). doi:10.1088/1757-899X/4/1/012011.CrossRefGoogle Scholar
Narayanan, T.S.N.S. and Lee, M.: Characteristics of microarc oxidation coatings deposited on magnesium using alkaline and acidic electrolytes in a single stage as well as using dual electrolytes in two stages. J. Alloys Compd. 687, 720 (2016).CrossRefGoogle Scholar
Bakhsheshi-Rad, H.R., Hamzah, E., Ebrahimi-Kahrizsangi, R., and Daroonparvar, M.: Fabrication and characterization of hydrophobic microarc oxidation/poly-lactic acid duplex coating on biodegradable Mg–Ca alloy for corrosion protection. Vaccum 125, 185 (2016).CrossRefGoogle Scholar
Daroonparvar, M., Azizi, M., Yajid, M., and Mohd, N.: Preparation and corrosion resistance of a nanocomposite plasma electrolytic oxidation coating on Mg-1% Ca alloy formed in aluminate electrolyte containing titania nano-additives. J. Alloys Compd. 688, 841 (2016).CrossRefGoogle Scholar