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Bicomponent nanofibrous scaffolds with dual release of anticancer drugs and biomacromolecules

Published online by Cambridge University Press:  04 March 2019

Yu Zhou ,
Qilong Zhao Open the ORCID record for Qilong Zhao [Opens in a new window] ,
Natasha L.Y. Tsai  and
Min Wang
Yu Zhou
Affiliation:
Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong
Qilong Zhao*
Affiliation:
Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, 518055, China
Natasha L.Y. Tsai
Affiliation:
Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong
Min Wang*
Affiliation:
Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong
*
Address all correspondence to Dr. Q. Zhao, Prof. M. Wang at ql.zhao@siat.ac, memwang@hku.hk
Address all correspondence to Dr. Q. Zhao, Prof. M. Wang at ql.zhao@siat.ac, memwang@hku.hk
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Abstract

Multifunctional scaffolds with dual release of small molecular drugs and biomacromolecules have potential in many applications such as cancer postoperative care, which require appropriate administration of anticancer drugs and biomacromolecules in a spatiotemporal manner. Herein, a systematic investigation into the dual release of anticancer drugs and biomacromolecules from the bicomponent nanofibrous scaffolds is performed. Their release behavior is affected by different fabrication techniques and different polymers used. We show that the bicomponent scaffold fabricated by dual-source dual-power emulsion electrospinning enables dual release of anticancer drugs and biomacromolecules in a controlled manner, holding promise for combinational cancer postoperative care.

Type
Research Letters
Information
MRS Communications , Volume 9 , Issue 1 , March 2019 , pp. 413 - 420
Copyright
Copyright © Materials Research Society 2019 

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