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Quartz tuning fork as a mass sensitive biosensor platform with a bi-layer film modification via plasma polymerization

Published online by Cambridge University Press:  03 May 2019

Hatice Ferda Özgüzar ,
Gizem Kaleli Can ,
Gözde Kabay  and
Mehmet Mutlu
Hatice Ferda Özgüzar
Affiliation:
Plasma Aided Biomedical Research Group (pabmed), Biomedical Engineering Division, Graduate School of Science and Technology, TOBB University of Economics and Technology, Ankara 06560, Turkey
Gizem Kaleli Can
Affiliation:
Plasma Aided Biomedical Research Group (pabmed), Biomedical Engineering Division, Graduate School of Science and Technology, TOBB University of Economics and Technology, Ankara 06560, Turkey Department of Biomedical Engineering, İzmir Democracy University, İzmir 35140, Turkey
Gözde Kabay
Affiliation:
Plasma Aided Biomedical Research Group (pabmed), Biomedical Engineering Division, Graduate School of Science and Technology, TOBB University of Economics and Technology, Ankara 06560, Turkey
Mehmet Mutlu*
Affiliation:
Plasma Aided Biomedical Research Group (pabmed), Biomedical Engineering Division, Graduate School of Science and Technology, TOBB University of Economics and Technology, Ankara 06560, Turkey Plasma Aided Biomedical Research Group (pabmed), Department of Biomedical Engineering, TOBB University of Economics and Technology, Ankara 06560, Turkey
*
Address all correspondence to Mehmet Mutlu at m.mutlu@etu.edu.tr
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Abstract

Due to the lack of the stability of amine films, a promising transducer, quartz-tuning fork (QTF) prongs were modified by a bi-layer film of plasma-polymerized n-heptane (hep) and then by ethylenediamine (EDA), respectively. For this purpose, the authors investigate the stability of amine-rich thin films both in air and aqueous medium. EDA films were deposited on QTF substrates by using an RF plasma system. The final amine-rich thin film was used to immobilize biologic recognition element. Model protein studies were showed that selected thin films could be adapted to QTF transducers to be used as a biosensor template.

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Type
Research Letters
Information
MRS Communications , Volume 9 , Issue 2 , June 2019 , pp. 710 - 718
Copyright
Copyright © Materials Research Society 2019 

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Footnotes

*

On leave.

References

1.Mutlu, M., Mutlu, S., Rosenberg, M.F., Kane, J., Jones, M.N., and Vadgama, P.: Matrix surface modification by plasma polymerization for enzyme immobilization. J. Mater. Chem. 1, 447–450 (1991).Google Scholar
2.Şen, Y., Baǧci, U., Güleç, H.A., and Mutlu, M.: Modification of food-contacting surfaces by plasma polymerization technique: reducing the biofouling of microorganisms on stainless steel surface. Food Bioprocess Technol. 5, 166–175 (2012).Google Scholar
3.Çökeliler, D., Erkut, S., Zemek, J., Biederman, H., and Mutlu, M.: Modification of glass fibers to improve reinforcement: a plasma polymerization technique. Dent. Mater. 23, 335–334 (2007).Google Scholar
4.Mutlu, S., Çökeliler, D., Shard, A., Göktaş, H., and Ozansoy, B.: Preparation and characterization of ethylenediamine and cysteamine plasma polymerized films on piezoelectric quartz crystal surfaces for a biosensor. Thin Solid Films 516, 1249–1255 (2008).Google Scholar
5.Çökeliler, D. and Mutlu, M.: Performance of amperometric alcohol electrodes prepared by plasma polymerization technique. Anal. Chim. Acta 469, 217–223 (2002).Google Scholar
6.Güleç, H.A., Sarioǧlu, K., and Mutlu, M.: Modification of food contacting surfaces by plasma polymerisation technique. Part I: determination of hydrophilicity, hydrophobicity and surface free energy by contact angle method. J. Food Eng. 75, 187–195 (2006).Google Scholar
7.Förch, R., Chifen, A.N., Bousquet, A., Khor, H.L., Jungblut, M., Chu, L.Q., Zhang, Z., Osey-Mensah, I., Sinner, E.-K., and Knoll, W.: Recent and expected roles of plasma-polymerized films for biomedical applications. Chem. Vap. Deposition 13, 280–294 (2007).Google Scholar
8.Tur, E., Onal-Ulusoy, B., Akdogan, E., and Mutlu, M.: Surface modification of polyethersulfone membrane to improve its hydrophobic characteristics for waste frying oil filtration: radio frequency plasma treatment. J. Appl. Polym. Sci. 123, 3402–3411 (2012).Google Scholar
9.Zhao, C., Li, L.Y., Guo, M.M., and Zheng, J.: Functional polymer thin films designed for antifouling materials and biosensors. Chem. Pap. 66, 523–668 (2012).Google Scholar
10.Förch, R., Zhang, Z., and Knoll, W.: Soft plasma treated surfaces: tailoring of structure and properties for biomaterial applications. Plasma Processes Polym. 2, 351–372 (2005).Google Scholar
11.Siow, K.S., Britcher, L., Kumar, S., and Griesser, H.J.: Plasma methods for the generation of chemically reactive surfaces for biomolecule immobilization and cell colonization—a review. Plasma Processes Polym. 3, 392–418 (2006).Google Scholar
12.Kaleli Can, G., Özgüzar, H.F., Kabay, G., Kömürcü, P., and Mutlu, M.: Simultaneous insulation and modification of quartz tuning fork surface by single-step plasma polymerization technique with amine-rich precursors. MRS Commun. 8, 541–549 (2018).Google Scholar
13.Ruiz, J.C., St-Georges-Robillard, A., Thérésy, C., Lerouge, S., and Wertheimer, M.R.: Fabrication and characterisation of amine-rich organic thin films: focus on stability. Plasma Process. Polym. 7, 737–753 (2010).Google Scholar
14.Denis, L., Cossement, D., Godfroid, T., Renaux, F., Bittencourt, C., Synders, R., and Hecq, M.: Synthesis of allylamine plasma polymer films: correlation between plasma diagnostic and film characteristics. Plasma Process. Polym 6, 199–208 (2009).Google Scholar
15.Harsch, A., Calderon, J., Timmons, R.B., and Gross, G.W.: Pulsed plasma deposition of allylamine on polysiloxane: a stable surface for neuronal cell adhesion. J. Neurosci. Methods 98, 135–144 (2000).Google Scholar
16.Ryssy, J., Prioste-Amaral, E., Assuncao, D.F.N., Rogers, N., Kirby, G.T.S., Smith, L.E., and Michelmore, A.: Chemical and physical processes in the retention of functional groups in plasma polymers studied by plasma phase mass spectroscopy. Phys. Chem. Chem. Phys. 18, 4496–4504 (2016).Google Scholar
17.Choukourov, A., Biederman, H., Slavinska, D., Trchova, M., and Hollander, A.: The influence of pulse parameters on film composition during pulsed plasma polymerization of diaminocyclohexane. Surf. Coatings Technol. 174–175, 863–866 (2003).Google Scholar
18.Gölander, C.G., Rutland, M.W., Cho, D.L., Johansson, A., Ringblom, H., Jönsson, S., and Yasuda, H.K.: Structure and surface properties of diaminocyclohexane plasma polymer films. J. Appl. Polym. Sci. 49, 39–51 (1993).Google Scholar
19.Gengenbach, T.R., Chatelier, R.C., and Griesser, H.J.: Correlation of the nitrogen 1s and oxygen 1s XPS binding energies with compositional changes during oxidation of ethylene diamine plasma polymers. Surf. Interface Anal. 24, 611–619 (1996).Google Scholar
20.Vasilev, K., Britcher, L., Casanal, A., and Griesser, H.J.: Solvent-induced porosity in ultrathin amine plasma polymer coatings. J. Phys. Chem. B 112, 10915–10921 (2008).Google Scholar
21.Manakhov, A., Zajickova, L., Elias, M., Cechal, J., Polcak, J., Hnilica, J., Bittnerova, S., and Necas, D.: Optimization of cyclopropylamine plasma polymerization toward enhanced layer stability in contact with water. Plasma Process. Polym. 11, 532–544 (2014).Google Scholar
22.Denis, L., Marsal, P., Olivier, Y., Godfroid, T., Lazzaroni, R., Hecq, M., Cornil, J., and Synders, R.: Deposition of functional organic thin films by pulsed plasma polymerization: a joint theoretical and experimental study. Plasma Process. Polym. 7, 172–181 (2010).Google Scholar
23.Buddhadasa, M. and Girard-Lauriault, P.L.: Plasma co-polymerisation of ethylene, 1,3-butadiene and ammonia mixtures: amine content and water stability. Thin Solid Films 591, 76–85 (2015).Google Scholar
24.Contreras-Garcia, A. and Wertheimer, M.R.: Low-pressure plasma polymerization of acetylene-ammonia mixtures for biomedical applications. Plasma Chem. Plasma Process. 33, 147–163 (2013).Google Scholar
25.Kaleli Can, G.: Development of QTF-Based Mass Sensitive Immunosensor for Phenylketonuria Diagnosis. (TOBB University of Economics and Technology, ANKARA, 2018).Google Scholar
26.Guimond, S., Hanselmann, B., Amberg, M., and Hegemann, D.: Plasma functionalization of textiles: specifics and possibilities. Pure Appl. Chem. 82, 559–629 (2010).Google Scholar
27.Robertson, J.: Diamond-like amorphous carbon. Mater. Sci. Eng. R Rep. 37, 129–281 (2002).Google Scholar
28.Atia, W.A. and Davis, C.C.: A phase-locked shear-force microscope for distance regulation in nearfield optical microscopy. Appl. Phys. Lett. 70, 405 (1997).Google Scholar
29.Allen, S., Chen, X., Davies, J., Davies, M.C., Dawkes, A.C., Edwards, J.C., Roberts, C.J., Sefton, J., Tendler, S.J.B., and Williams, P.M.: Detection of antigen-antibody binding events with the atomic force microscope. Biochemistry 36, 7457–7463 (1997).Google Scholar
30.Giessibl, F.J.: Atomic resolution on Si(111)-(7 × 7) by noncontact atomic force microscopy with a force sensor based on a quartz tuning fork. Appl. Phys. Lett. 76, 1470 (2000).Google Scholar
31.Göttlich, H., Stark, R.W., Pedarnig, J.D., and Heckl, W.M.: Noncontact scanning force microscopy based on a modified tuning fork sensor. Rev. Sci. Instrum. 71, 3104 (2000).Google Scholar
32.Kühn, S., Hettich, C., Schmitt, C., Poizat, J.P.H., and Sandoghdar, V.: Diamond colour centres as a nanoscopic light source for scanning near-field optical microscopy. J. Microsc. 202, 2–6 (2001).Google Scholar
33.Schmidt, J.U., Bergander, H., and Eng, L.M.: Experimental and theoretical analysis of shear-force interaction in the non-contact regime with 100 pN force resolution. Appl. Surf. Sci. 157, 295–301 (2000).Google Scholar
34.Friedt, J.M. and Carry, É: Introduction to the quartz tuning fork. Am. J. Phys. 75, 415 (2007).Google Scholar
35.Su, X., Dai, C., Zhang, J., and O'Shea, S.J.: Quartz tuning fork biosensor. Biosens. Bioelectron 17, 111–117 (2002).Google Scholar
36.Rupper, P., Vandenbossche, M., Bernard, L., Hegemann, D., and Heuberger, M.: Composition and stability of plasma polymer films exhibiting vertical chemical gradients. Langmuir 33, 2340–2352 (2017).Google Scholar
37.Vandenbossche, M. and Hegemann, D.: Recent approaches to reduce aging phenomena in oxygen- and nitrogen-containing plasma polymer films: an overview. Curr. Opin. Solid State Mater. Sci. 22, 26–38 (2018).Google Scholar
38.Nasrin, R., Hossain, K.S., and Bhuiyan, A.H.: Morphological, elemental, and optical characterization of plasma polymerized n-butyl methacrylate thin films. Appl. Phys. A 124, 391 (2018).Google Scholar
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