Hostname: page-component-857557d7f7-nbs69 Total loading time: 0 Render date: 2025-11-26T01:11:36.923Z Has data issue: false hasContentIssue false

Patternable Rough Textured Gold Microwire for NeurochemicalSensing

Published online by Cambridge University Press:  18 January 2016

Eva Mutunga
Affiliation:
Bredesen Center, University of Tennessee, 418 Greve Hall, 821 Volunteer Blvd, Knoxville, TN 37996, U.S.A.
Pawan Tyagi*
Affiliation:
Mechanical Engineering Department, University of the District of Columbia, 4200 Connecticut Ave. N.W., Washington DC, U.S.A.
*
*(Email: ptyagi@udc.edu)
Get access

Abstract

Understanding spatial and temporal neuronal activities is crucial for finding thecure for brain related ailments and advancement of our knowledge about the brainitself. This paper discusses our recent finding of the patternable roughtextured gold microwire for neurochemical sensing. We have successfullyfabricated the ∼5 µm wide and ∼ 60 nm thick goldmicrowires based electrochemical sensor. We produced these microwires along theedge of lithographically patterned nickel thin film. A nickel thin film edge wasshadowed by the photoresist overhang during electrochemical growth only to allowgold deposition along the edges. Our electrochemical growth conditions yieldedvery rough textured sensor. Rough textured biosensors are highly desirable forincreasing surface/volume ratio for efficient electrochemical sensing. Theserough-textured microwires were transformed into the functional neurochemicalsensor to detect dopamine. Our voltammetry and chronoamperometry studies onrough textured microwires based sensor confirmed the successful detection ofdopamine.

Information

Type
Articles
Copyright
Copyright © Materials Research Society 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

REFERENCES

Zachek, M.K., Hermans, A., Wightman, R.M., and Mccarty, G.S., Journal of Electroanalytical Chemistry 614, 113 (2008).CrossRefGoogle Scholar
Garris, P.A., Ciolkowski, E.L., Pastore, P., and Wightman, R.M., Journal of Neuroscience 14 (10), 60846093 (1994).Google Scholar
Schultz, W., Nature Reviews Neuroscience 1, 199 (2000).Google Scholar
Venton, B.J. and Wightman, R.M., Analytical Chemistry 75 (19), 414A421A (2003).Google Scholar
Cooper, J.S., Bloom, F.E. and Roth, R.H., The biological basis of Neuropharmacology, 8th ed. (Oxford University Press, New York, 2002).Google Scholar
Phillips, P.E., Stuber, G.D., Heien, M.L., Wightman, R.M. and Carelli, R.M., Nature 422, 614 (2003).Google Scholar
Tyagi, P., Postetter, D., Saragnese, D.L., Randall, C.L., Mirski, M.A. and Gracias, D.H., Anal. Chem. 81, 9979 (2009).Google Scholar
Penner, R.M., Heben, M.J., Longin, T. L. and Lewis, N.S., Science 250 (4984), 11181121 (1990).Google Scholar
Arrigan, D. W. M., Chemical MicroAnalytics 129, 1157 (2004).Google Scholar
Xiang, C., Kung, S., Taggart, D.K., Yang, F., Thompson, M.A., Guell, A.G., Yang, Y. and Penner, R.M., ACS Nano 2 (9), 19391949 (2008).CrossRefGoogle Scholar