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Nanomaterial synthesis and characterization for toxicological studies: TiO2 case study

Published online by Cambridge University Press:  05 July 2018

E. Valsami-Jones ,
D. Berhanu ,
A. Dybowska ,
S. Misra ,
A. R. Boccaccini ,
T. D. Tetley ,
S. N. Luoma  and
J. A. Plant
E. Valsami-Jones*
Affiliation:
Department of Mineralogy, Natural History Museum, Cromwell Road, London, SW7 5BD, UK
D. Berhanu
Affiliation:
Department of Mineralogy, Natural History Museum, Cromwell Road, London, SW7 5BD, UK Department of Materials, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3 6LY, UK
A. Dybowska
Affiliation:
Department of Mineralogy, Natural History Museum, Cromwell Road, London, SW7 5BD, UK
S. Misra
Affiliation:
Department of Mineralogy, Natural History Museum, Cromwell Road, London, SW7 5BD, UK Department of Materials, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK
A. R. Boccaccini
Affiliation:
Department of Materials, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK
T. D. Tetley
Affiliation:
National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3 6LY, UK
S. N. Luoma
Affiliation:
U.S. Geological Survey, 345 Middlefield Rd, MS496, Menlo Park, CA 94025, USA Department of Zoology, Natural History Museum, Cromwell Road, London, SW7 5BD, UK
J. A. Plant
Affiliation:
Department of Earth Science and Engineering, Imperial College London, Exhibition Road, London, SW7 2AZ, UK
*
*E-mail: E.Valsami-Jones@nhm.ac.uk
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Abstract

In recent years it has become apparent that the novel properties of nanomaterials may predispose them to a hitherto unknown potential for toxicity. A number of recent toxicological studies of nanomaterials exist, but these appear to be fragmented and often contradictory. Such discrepancies may be, at least in part, due to poor description of the nanomaterial or incomplete characterization, including failure to recognise impurities, surface modifications or other important physicochemical aspects of the nanomaterial. Herew em ake a casef or the importance of good quality, well-characterized nanomaterials for future toxicological studies, combined with reliable synthesis protocols, and we present our efforts to generate such materials. The model system for which we present results is TiO2 nanoparticles, currently used in a variety of commercial products.

Keywords

nanomaterialsnanoparticlesanataserutileTiO2synthesistoxicologynanoform
Type
Research Article
Information
Mineralogical Magazine , Volume 72 , Issue 1 , February 2008 , pp. 515 - 519
Copyright
Copyright © The Mineralogical Society of Great Britain and Ireland 2008

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