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Application of Hybrid Models to Blood Cell Production in theBone Marrow

Published online by Cambridge University Press:  15 June 2011

N. Bessonov ,
F. Crauste ,
S. Fischer ,
P. Kurbatova  and
V. Volpert
N. Bessonov
Affiliation:
Institute of Mechanical Engineering Problems, 199178 Saint Petersburg, Russia Institut Camille Jordan, Université Lyon 1, UMR 5208 CNRS 69622 Villeurbanne, France
F. Crauste
Affiliation:
Institut Camille Jordan, Université Lyon 1, UMR 5208 CNRS 69622 Villeurbanne, France INRIA Rhône-Alpes, Team-project “Dracula”
S. Fischer
Affiliation:
Institut Camille Jordan, Université Lyon 1, UMR 5208 CNRS 69622 Villeurbanne, France INRIA Rhône-Alpes, Team-project “Dracula”
P. Kurbatova
Affiliation:
Institut Camille Jordan, Université Lyon 1, UMR 5208 CNRS 69622 Villeurbanne, France INRIA Rhône-Alpes, Team-project “Dracula”
V. Volpert*
Affiliation:
Institut Camille Jordan, Université Lyon 1, UMR 5208 CNRS 69622 Villeurbanne, France INRIA Rhône-Alpes, Team-project “Dracula”
*
⋆ Corresponding author. E-mail: volpert@math.univ-lyon1.fr
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Abstract

A hybrid model of red blood cell production, where cells are considered as discreteobjects while intra-cellular proteins and extra-cellular biochemical substances aredescribed with continuous models, is proposed. Spatial organization and regulation of redblood cell production (erythropoiesis) are investigated. Normal erythropoiesis issimulated in two dimensions, and the influence on the output of the model of someparameters involved in cell fate (differentiation, self-renewal, and death by apoptosis)is studied.

Keywords

hybrid modelserythropoiesisregulatory mechanisms

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