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Social Attention in 47,XXY (Klinefelter Syndrome): Visual Scanning of Facial Expressions Using Eyetracking

Published online by Cambridge University Press:  28 May 2015

Sophie van Rijn
Sophie van Rijn*
Affiliation:
Clinical Child and Adolescent Studies, Leiden University, Leiden, the Netherlands Leiden Institute for Brain and Cognition, Leiden, The Netherlands
*
Correspondence and reprint requests to: Sophie van Rijn, Clinical Child and Adolescent Studies, Leiden University, Wassenaarseweg 52, 2333 AK, Leiden, the Netherlands. E-mail: srijn@fsw.leidenuniv.nl
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Abstract

Boys and men with an extra X chromosome (47,XXY, Klinefelter syndrome) are at risk for problems in social functioning and have an increased vulnerability for autism spectrum disorders (ASD). In the search for underlying mechanisms driving this increased risk, this study focused on social attention, that is, spontaneous orientation toward facial expressions. Seventeen adults with 47,XXY and 20 non-clinical controls participated in this study. Social attention was measured using an eyetracking method that quantifies the visual scanning patterns of faces expressing different types of emotions (happy, fearful, angry, neutral) and their varying intensity levels (25%, 50%, 75%, 100%). Overall, the group with Klinefelter syndrome fixated less on the eye region of faces when compared to controls (Cohen’s d 1.4), and did not show the typical tendency, as was found in the control group, to first fixate on the eyes when presented with a face (Cohen’s d 1.0). There was no significant effect of type or intensity of emotion. Shorter looking times toward eyes showed a borderline significant correlation with self-reports of poorer social functioning, with 29% explained variance. These findings suggest a reduced tendency to rapidly and automatically attend to the eyes of others in individuals with 47,XXY. This may have impact on more complex social-cognitive abilities that build upon this. In addition to studies of behaviorally defined disorders such as ASD, studying individuals with Klinefelter syndrome provide insight into mechanisms underlying various “at risk” pathways of social dysfunction and the factors that mediate this risk. (JINS, 2015, 21, 364–372)

Keywords

Klinefeltersocial attentioneyetrackingfacesemotionautism

Information

Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 21 , Issue 5 , May 2015 , pp. 364 - 372
Copyright
Copyright © The International Neuropsychological Society 2015 

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References

Achenbach, T.M., & Rescorla, L.A. (2003). Manual for the ASEBA: Adult forms & profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth & Families.Google Scholar
Arrindell, W.A., Bridges, K.R., van der Ende, J., St. Lawrence, J.S., Gray-Shellberg, L., Harnish, R., & Sanderman, R. (2001). Normative studies with the Scale for Interpersonal Behaviour (SIB): 2. US students: A cross-cultural comparison with Dutch data. Behaviour Research and Therapy, 39(12), 1461–1479.CrossRefGoogle Scholar
Arrindell, W.A., de Groot, P.M., & Walburg, J.A. (1984). The scale for interpersonal behavior; Manual part 1. Lisse, the Netherlands: Swets & Zeitlinger.Google Scholar
Arrindell, W.A., & Van der Ende, J. (1985). Cross-sample invariance of the structure of self-reported distress and difficulty in assertiveness: Experiences with the Scale for Interpersonal Behaviour. Advances in Behaviour Research and Therapy, 7, 205–243.CrossRefGoogle Scholar
Bishop, D.V., Jacobs, P.A., Lachlan, K., Wellesley, D., Barnicoat, A., Boyd, P.A., & Scerif, G. (2011). Autism, language and communication in children with sex chromosome trisomies. Archives of Disease in Childhood, 10, 954–959.CrossRefGoogle Scholar
Boada, R., Janusz, J., Hutaff-Lee, C., & Tartaglia, N. (2009). The cognitive phenotype in Klinefelter syndrome: A review of the literature including genetic and hormonal factors. Developmental Disabilities Research Reviews, 15(4), 284–294.Google Scholar
Bojesen, A., Juul, S., & Gravholt, C.H. (2003). Prenatal and postnatal prevalence of Klinefelter syndrome: A national registry study. The Journal of Clinical Endocrinology and Metabolism, 88(2), 622–626.CrossRefGoogle ScholarPubMed
Boone, K.B., Swerdloff, R.S., Miller, B.L., Geschwind, D.H., Razani, J., Lee, A., & Paul, L. (2001). Neuropsychological profiles of adults with Klinefelter syndrome. Journal of the International Neuropsychological Society, 7(4), 446–456.Google Scholar
Bouvard, M., Arrindell, W.A., Guerin, J., Bouchard, C., Rion, A.C., Ducottet, E., & Cottraux, J. (1999). Psychometric appraisal of the scale for interpersonal behavior (SIB) in France. Behaviour Research and Therapy, 37(8), 741–762.Google Scholar
Brandenburg-Goddard, M.N., Rijn, S.v., Rombouts, S.A. R.B., Veer, I.M., & Swaab, H. (2014). A comparison of neural correlates underlying social cognition in Klinefelter syndrome and autism. Social Cognitive and Affective Neuroscience, 9(1), e84721.Google Scholar
Bruining, H., Swaab, H., Kas, M., & Van Engeland, H. (2009). Psychiatric characteristics in a self-selected sample of boys with klinefelter syndrome. Pediatrics, 123(5), e865–e870.Google Scholar
Campbell, J.M. (1998). Internal and external validity of seven Wechsler Intelligence Scale for Children - Third Edition short forms in a sample of psychiatric inpatients. Psychological Assessment, 10(4), 431–434.Google Scholar
Cordeiro, L., Tartaglia, N., Roeltgen, D., & Ross, J. (2012). Social deficits in male children and adolescents with sex chromosome aneuploidy: A comparison of XXY, XYY, and XXYY syndromes. Research in Developmental Disabilities, 33(4), 1254–1263.Google Scholar
Dawson, G., Toth, K., Abbott, R., Osterling, J., Munson, J., Estes, A., & Liaw, J. (2004). Early social attention impairments in autism: Social orienting, joint attention, and attention to distress. Developmental Psychology, 40(2), 271–283.Google Scholar
Ekman, P., & Friesen, W. V. (1976). Pictures of facial affect. Palo Alto, CA: Consulting Psychologists Press.Google Scholar
Farzin, F., Rivera, S., & Hessl, D. (2009). Brief report: Visual processing of faces in individuals with fragile X syndrome: An eye tracking study. Journal of Autism and Developmental Disorders, 39(6), 946–952.Google Scholar
Geschwind, D.H., & Dykens, E. (2004). Neurobehavioral and psychosocial issues in Klinefelter syndrome. Learning Disabilities Research & Practice, 19(3), 166–173.Google Scholar
Grelotti, D.J., Gauthier, I., & Schultz, R.T. (2002). Social interest and the development of cortical face specialization: What autism teaches us about face processing. Developmental Psychobiology, 40(3), 213.Google Scholar
HerreraGraf, M., Dipert, Z.J., & Hinton, R.N. (1996). Exploring the effective use of the vocabulary/block design short form with a special school population. Educational and Psychological Measurement, 56(3), 522–528.CrossRefGoogle Scholar
Hess, U., Blairy, S., & Kleck, R. (1997). The intensity of emotional facial expressions and decoding accuracy. Journal of Nonverbal Behavior, 21(4), 241–257.Google Scholar
Hobson, R.P. (1993). Understanding persons: The role of affect. In S. Baron-Cohen, H. Tager-Flusberg & D. Cohen (Eds.), Understanding other minds. Oxford, UK: Oxford University Press.Google Scholar
Itier, R.J., & Batty, M. (2009). Neural bases of eye and gaze processing: The core of social cognition. Neuroscience and Biobehavioral Reviews, 33(6), 843–863.Google Scholar
Langton, S.R.H., Watt, R.J., & Bruce, V. (2000). Do the eyes have it? Cues to the direction of social attention. Trends in Cognitive Sciences, 4(2), 50–59.Google Scholar
Leggett, V., Jacobs, P., Nation, K., Scerif, G., & Bishop, D.V.M. (2010). Neurocognitive outcomes of individuals with a sex chromosome trisomy: XXX, XYY, or XXY: A systematic review. Developmental Medicine and Child Neurology, 52(2), 119–129.Google Scholar
Öhman, A. (1993). Fear and anxiety as emotional phenomena: Clinical phenomenology, evolutionary perspectives, and information processing mechanisms. In M.D. Lewis & J.M. Haviland (Eds.), Handbook of emotions (pp. 511–536). New York: Guilford.Google Scholar
Papagiannopoulou, E.A., Chitty, K.M., Hermens, D.F., Hickie, I.B., & Lagopoulos, J. (2014). A systematic review and meta-analysis of eye-tracking studies in children with autism spectrum disorders. Social Neuroscience, 9(6), 610–632.Google ScholarPubMed
Ratcliffe, S. (1999). Long-term outcome in children of sex chromosome abnormalities. Archives of Disease in Childhood, 80(2), 192–195.Google Scholar
Ratcliffe, S., Butler, G.E., & Jones, M. (1991). Edinburgh study of growth and development of children with sex chromosome abnormalities- IV. Birth Defects: Original Articles Series 26(4), 1–44.Google Scholar
Robinson, A., Bender, B., Linden, M., & Salbenblatt, J. (1991). Sex chromosome aneuploidy: The Denver prospective study. Birth Defects: Original Articles Series, 26(4), 59–115.Google Scholar
Schyns, P.G., Petro, L.S., & Smith, M.L. (2007). Dynamics of visual information integration in the brain for categorizing facial expressions. Current Biology, 17(18), 1580–1585.Google Scholar
Stewart, D., Bailey, J., Netley, C., & Park, E. (1991). Growth, development and behavioral outcome from mid-adolescence to adulthood in subjects with chromosome aneuploidy: The Toronto study. Birth Defects: Original Articles Series, 26(4), 131–188.Google Scholar
Tartaglia, N., Cordeiro, L., Howell, S., Wilson, R., & Janusz, J. (2010). The spectrum of the behavioral phenotype in boys and adolescents 47,XXY (Klinefelter syndrome). Pediatr Endocrinol Rev, 8(Suppl. 1), 151–159.Google Scholar
van 't Wout, M., van Rijn, S., Jellema, T., Kahn, R.S., & Aleman, A. (2009). Deficits in implicit attention to social signals in schizophrenia and high risk groups: Behavioural evidence from a new illusion. PLoS One, 4(5), e5581.Google Scholar
van Rijn, S., Barendse, M., van Goozen, S., & Swaab, S. (2014). Social attention, affective arousal and empathy in men with Klinefelter syndrome (47,XXY): Evidence from eyetracking and skin conductance. PLoS One, 9, e84721.Google Scholar
van Rijn, S., Stockmann, L., Borghgraef, M., Bruining, H., van Raavenswaaij-Arts, C., Govaerts, L., & Swaab, H. (2014). The social behavioral phenotype in boys and girls with an extra X chromosome: A comparison with autism spectrum disorder. Journal of Autism and Developmental Disorders, 44(2), 310–320.Google Scholar
van Rijn, S., Stockmann, L., van Buggenhout, G., van Ravenswaaij-Arts, C., & Swaab, H. (2014). Social cognition and underlying cognitive mechanisms in children with an extra X chromosome: A comparison with autism spectrum disorder. Genes Brain and Behavior, 13(5), 459–467.Google Scholar
van Rijn, S., Swaab, H., Aleman, A., & Kahn, R.S. (2006). X Chromosomal effects on social cognitive processing and emotion regulation: A study with Klinefelter men (47,XXY). Schizophrenia Research, 84(2-3), 194–203.CrossRefGoogle Scholar
van Rijn, S., Swaab, H., Aleman, A., & Kahn, R.S. (2008). Social behavior and autism traits in a sex chromosomal disorder: Klinefelter (47XXY) syndrome. Journal of Autism and Developmental Disorders, 38(9), 1634–1641.Google Scholar
Vinette, C., Gosselin, F., & Schyns, P.G. (2004). Spatio-temporal dynamics of face recognition in a flash: It’s in the eyes. Cognitive Science, 28(2), 289–301.Google Scholar
Visootsak, J., & Graham, J.M. (2009). Social function in multiple X and Y chromosome disorders: XXY, XYY, XXYY, XXXY. Developmental Disabilities Research Reviews, 15(4), 328–332.Google Scholar
Wechsler, D. (1997). Wechsler Adult Intelligence Scale-Third Edition (WAIS-III). San Antonio, TX: The Psychological Corporation.Google Scholar
Wechsler, D. (2005). WAIS-III NL. Wechsler Adult Intelligence Scale WAIS-III (Third edition, Dutch version. Manual. Amsterdam: Harcourt Test Publishers.Google Scholar