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Prospective Memory and Antiretroviral Medication Non-Adherence in HIV: An Analysis of Ongoing Task Delay Length Using the Memory for Intentions Screening Test

Published online by Cambridge University Press:  25 October 2012

Amelia J. Poquette ,
David J. Moore ,
Ben Gouaux ,
Erin E. Morgan ,
Igor Grant ,
Steven Paul Woods  and
The HNRP Group
Amelia J. Poquette
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, California
David J. Moore*
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, California
Ben Gouaux
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, California
Erin E. Morgan
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, California
Igor Grant
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, California
Steven Paul Woods
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, California
*
Correspondence and reprint requests to: David J. Moore, Department of Psychiatry (8231), University of California, San Diego, 220 Dickinson Street, Suite B, San Diego, CA, USA 92103. E-mail: djmoore@ucsd.edu
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Abstract

Using multi-process framework by McDaniel and Einstein (2000), the current study examined whether the length of prospective memory (PM) delay intervals as measured by the 2- and 15-min subscales of the Memory for Intentions Screening Test (MIST) have differential predictive value for antiretroviral (ARV) adherence. Participants included 74 HIV-infected individuals whose ARV adherence was tracked with an electronic monitoring system. Participants were classified as “adherent” (n = 49) or “non-adherent” (n = 25) based on recorded pill bottle openings of ≥90% of prescribed doses over 30 days. An adherence group by MIST delay interval interaction was observed, such that non-adherent participants had worse performance on the 15-min, but not 2-min delay PM MIST subscales. The observed MIST 15-min delay effects were significantly more pronounced on time- versus event-cued PM trials. Long-delay time-based PM was predictive of non-adherence independent of demographics, mood state, self-reported adherence, and general cognitive functioning. Findings from this clinical study indicate that ARV non-adherence may be particularly associated with deficits in strategic cue monitoring over longer PM delays, which may inform interventions to improve adherence among persons living with HIV infection. (JINS, 2012, 18, 1–7)

Keywords

Episodic memoryMedication adherenceEveryday functioningNeuropsychological assessmentExecutive functionsAIDS dementia complex

Information

Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 19 , Issue 2 , February 2013 , pp. 155 - 161
Copyright
Copyright © The International Neuropsychological Society 2012

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