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Pre-dementia Memory Impairment is Associated with White Matter Tract Affection

Published online by Cambridge University Press:  24 November 2010

Ramune Grambaite ,
Ivar Reinvang ,
Per Selnes ,
Anders M. Fjell ,
Kristine B. Walhovd ,
Vidar Stenset  and
Tormod Fladby
Ramune Grambaite*
Affiliation:
Department of Neurology, Akershus University Hospital, Lørenskog, Norway Akershus University Hospital Research Center, Lørenskog, Norway
Ivar Reinvang
Affiliation:
Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway
Per Selnes
Affiliation:
Department of Neurology, Akershus University Hospital, Lørenskog, Norway Faculty Division Akershus University Hospital, University of Oslo, Oslo, Norway
Anders M. Fjell
Affiliation:
Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway Department of Neuropsychology, Oslo University Hospital Ulleval, Oslo, Norway
Kristine B. Walhovd
Affiliation:
Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway Department of Neuropsychology, Oslo University Hospital Ulleval, Oslo, Norway
Vidar Stenset
Affiliation:
Department of Neurology, Akershus University Hospital, Lørenskog, Norway Faculty Division Akershus University Hospital, University of Oslo, Oslo, Norway Department of Neurosurgery, Oslo University Hospital Ulleval, Oslo, Norway
Tormod Fladby
Affiliation:
Department of Neurology, Akershus University Hospital, Lørenskog, Norway Faculty Division Akershus University Hospital, University of Oslo, Oslo, Norway
*
Correspondence and reprint requests to: Ramune Grambaite, Department of Neurology, Akershus University Hospital, Sykehusveien 25, NO-1478 Lørenskog, Norway. E-mail: ramuneg@psykologi.uio.no
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Abstract

Mild cognitive impairment (MCI), especially amnestic, often represents pre-dementia Alzheimer’s disease, characterized by medial temporal lobe atrophy, while white matter (WM) alterations are insufficiently described. We analyze both cortical morphometric and WM diffusivity differences in amnestic versus non-amnestic subtypes and ask if memory and WM tract affection are related independently of cortical atrophy. Forty-nine patients from a university-hospital based memory clinic with a score of 3 on the Global Deterioration Scale aged 43–77 years (45% female) were included. Two neuropsychologists have classified cases as amnestic (aMCI), non-amnestic (naMCI), or less advanced (laMCI), not satisfying criteria for aMCI/naMCI. Diffusion tensor imaging (DTI) WM tract and morphometric data of the temporal-parietal memory network were compared among patient subtypes and related to story, word list, and visual memory. WM radial and mean diffusivity (DR and MD), underlying the entorhinal cortex, were higher in aMCI compared with laMCI. WM DR and MD, underlying the entorhinal, parahippocampal, and middle temporal cortex, explained unique variance in word list and story memory, and this was not due to secondary effects of cortical thinning. DTI may thus potentially aid diagnosis in early disease stages. (JINS, 2011, 17, 000–000)

Keywords

Alzheimer’s diseaseMild cognitive impairmentDiffusion tensor imagingRadial and mean diffusivityCortical thicknessTemporal-parietal memory network
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 1 , January 2011 , pp. 143 - 153
Copyright
Copyright © The International Neuropsychological Society 2010

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