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Management of neuroendocrine small cell carcinoma of cervix-a single centre retrospective study

Published online by Cambridge University Press:  02 April 2012

Ursula Mcgivern ,
Jacqueline Clarke ,
Anne Drake ,
Glenn McGluggage  and
Jonathan McAleese
Ursula Mcgivern*
Affiliation:
Belfast City Hospital, Belfast, United Kingdom
Jacqueline Clarke
Affiliation:
Belfast City Hospital, Belfast, United Kingdom
Anne Drake
Affiliation:
Belfast City Hospital, Belfast, United Kingdom
Glenn McGluggage
Affiliation:
Belfast City Hospital, Belfast, United Kingdom
Jonathan McAleese
Affiliation:
Belfast City Hospital, Belfast, United Kingdom
*
Correspondence to: Ursula Mcgivern, Belfast City Hospital, Belfast, United Kingdom. E-mail: ursulamcgivern@doctors.org.uk
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Abstract

Purpose: To determine disease-free and overall survival of neuroendocrine small cell cancer of cervix treated at the Northern Ireland Cancer centre between 1999 and 2010.

Materials and methods: A retrospective review of all patients diagnosed and treated with neuroendocrine small cell cancer of cervix in Northern Ireland. Details of treatment modality including chemotherapy, radiotherapy and surgery were recorded.

Results: Fifteen patients diagnosed with neuroendocrine small cell carcinoma (NSCC) of cervix were identified between 1999 and 2010, twelve with disease localised to the pelvis and three with metastatic disease. Three-year overall survival for all patients was 65% and disease-free survival was 45% for all patients. In patients with pelvic confined disease 3-year overall survival was 79% and disease-free survival was 57%. Median disease-free and overall survival was 30 and 39.6 months respectively. These survival rates compare very favourably to those reported in the literature. Stage of disease at diagnosis was the main determinant of survival.

Conclusion: Local control and survival can be achieved in NSCC of patients with a combination of irradiation and platinum-based chemotherapy. Stage of disease determines outcomes.

Keywords

Cervical carcinomaNeuroendocrine small cell carcinomaRadiotherapy
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 12 , Issue 2 , June 2013 , pp. 146 - 153
Copyright
Copyright © Cambridge University Press 2012

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