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Bullous pemphigoid development during the course of breast cancer: a radiation induced or a radiation recall dermatitis?

Published online by Cambridge University Press:  25 September 2020

Mouna Ben Rejeb Open the ORCID record for Mouna Ben Rejeb [Opens in a new window] ,
Rim Moujahed ,
Alia Zehani  and
Lotfi Kochbati
Mouna Ben Rejeb*
Affiliation:
Radiation Oncology Department, Abderrahman Mami Hospital, Ariana, Tunisia Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
Rim Moujahed
Affiliation:
Radiation Oncology Department, Abderrahman Mami Hospital, Ariana, Tunisia Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
Alia Zehani
Affiliation:
Anatomic Pathology Department, La Rabta Hospital, Tunis, Tunisia Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
Lotfi Kochbati
Affiliation:
Radiation Oncology Department, Abderrahman Mami Hospital, Ariana, Tunisia Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
*
Author for correspondence: Mouna Ben Rejeb, Radiation Oncology Department, Abderrahman Mami Hospital, Route de Raoued 2080, Ariana, Tunisia. Tel: +216 94682772. E-mail: brjmouna@gmail.com
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Abstract

Background:

Bullous pemphigoid (BP) is the most common autoimmune bullous disease, which is usually seen in older ages. Rarely, radiotherapy (RT) has been reported as a localised trigger factor for BP.

Case:

We present a case of a 64-year-old woman who underwent radical mastectomy and radiation therapy for breast cancer. Two months after the completion of RT with adjuvant Trastuzumab, a BP eruption developed in the irradiated area, spreading thereafter to other skin areas. The patient was treated with oral corticosteroids and the lesions evolved favourably.

Conclusion:

This case demonstrates a relatively benign skin reaction that could develop during the course of cancer treatment, which required co-management by oncologists, pathologists and dermatologists.

Keywords

breast cancerradiotherapybullous pemphigoidTrastuzumab
Type
Case Study
Information
Journal of Radiotherapy in Practice , Volume 21 , Issue 1 , March 2022 , pp. 144 - 146
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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