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Synthesis and blood compatibilities of novel segmented polyurethanes containing phosphatidylcholine analogous moieties in the main chains and long-chain alkyl groups in the side chains

Published online by Cambridge University Press:  31 January 2011

Arata Korematsu ,
Yu-Jun Li ,
Takayuki Murakami  and
Tadao Nakaya
Arata Korematsu
Affiliation:
Department of Bioapplied Chemistry, Faculty of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan
Yu-Jun Li
Affiliation:
Department of Bioapplied Chemistry, Faculty of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan
Takayuki Murakami
Affiliation:
Department of Bioapplied Chemistry, Faculty of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan
Tadao Nakaya
Affiliation:
Department of Bioapplied Chemistry, Faculty of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan
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Abstract

New segmented polyurethanes containing phospholipid moieties in the main chains and long-chain alkyl groups in the side chains were synthesized. The soft segments used in this study were poly(butadiene), poly(isoprene), hydrogenated poly(isoprene), and poly(1,6-hexyl-1,2-ethylcarbonate) diol. The hard segments of these polyurethanes were 4,4′-methylenediphenyl diisocyanate, bis[2-(2-hydroxyethyldimethylammonio)ethyl]2-cetyl- 1,3-propanediphosphate, and 1,4-butanediol. The blood compatibilities of the new polymers were evaluated by platelet-rich plasma contact studies and viewed by scanning electron microscopy using medical grade BioSpan® and nonphospholipid polyurethane as references. These new materials have good surfaces in terms of platelet adhesion, and the morphology of adhered platelets undergoes a relatively low degree of variation.

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Type
Articles
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Journal of Materials Research , Volume 14 , Issue 9 , September 1999 , pp. 3789 - 3798
Copyright
Copyright © Materials Research Society 1999

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