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Surface modification of the biodegradable cardiovascular stent material Mg–Zn–Y–Nd alloy via conjugating REDV peptide for better endothelialization

Published online by Cambridge University Press:  06 November 2018

Li Chen ,
Jingan Li Open the ORCID record for Jingan Li [Opens in a new window] ,
Shuo Wang ,
Shijie Zhu ,
Chao Zhu ,
Boyuan Zheng ,
Ge Yang  and
Shaokang Guan
Li Chen
Affiliation:
School of Material Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy, Zhengzhou University, Zhengzhou 450001, People’s Republic of China
Jingan Li*
Affiliation:
School of Material Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy, Zhengzhou University, Zhengzhou 450001, People’s Republic of China
Shuo Wang
Affiliation:
School of Material Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy, Zhengzhou University, Zhengzhou 450001, People’s Republic of China
Shijie Zhu
Affiliation:
School of Material Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy, Zhengzhou University, Zhengzhou 450001, People’s Republic of China
Chao Zhu
Affiliation:
School of Material Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy, Zhengzhou University, Zhengzhou 450001, People’s Republic of China
Boyuan Zheng
Affiliation:
School of Material Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy, Zhengzhou University, Zhengzhou 450001, People’s Republic of China
Ge Yang
Affiliation:
School of Material Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy, Zhengzhou University, Zhengzhou 450001, People’s Republic of China
Shaokang Guan*
Affiliation:
School of Material Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy, Zhengzhou University, Zhengzhou 450001, People’s Republic of China
*
a)Address all correspondence to these authors. e-mail: lijingan@zzu.edu.cn
b)e-mail: skguan@zzu.edu.cn
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Abstract

Magnesium is a biodegradable material that has potential application in cardiovascular stent development: its excellent mechanical properties and blood compatibility make it highly useful in interventional therapy. Nevertheless, the following shortcomings restrict its further application: antihyperplasia function and promoting surface endothelialization. In this study, we immobilized a specific link peptide of endothelial cells, Arg-Glu-Asp-Val (REDV), onto polydopamine (PDA)-deposited Mg–Zn–Y–Nd alloy surface via covalent reaction to improve the growth of the endothelial cells. The PDA/REDV coating with optimized parameters maintained the good blood compatibility of the Mg–Zn–Y–Nd alloy at the biomimetic speed of the blood flow and significantly inhibited the growth of the vascular smooth muscle cells and macrophage attachment/activation, which indicated its better functions in antihyperplasia and anti-inflammation. In particular, the PDA/REDV coating not only showed consistent results in promoting the attachment of endothelial cells as reported elsewhere, but also displayed the ability of enhancing the viability of endothelial cells (or inhibiting apoptosis), suggesting its pro-endothelialized function through different pathways. In summary, this PDA/REDV coating addressed the above-mentioned shortcomings of the magnesium alloy, which may promise its wider application.

Keywords

biomaterialcoatingalloy
Type
Article
Information
Journal of Materials Research , Volume 33 , Issue 23 , 14 December 2018 , pp. 4123 - 4133
Copyright
Copyright © Materials Research Society 2018 

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