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Fabrication of polyelectrolyte microspheres using porous manganese carbonate as sacrificial template for drug delivery application

Published online by Cambridge University Press:  12 March 2019

Alexandro da Silva Abreu ,
Janicy Arantes Carvalho ,
Antonio Claudio Tedesco ,
Milton Beltrame Junior  and
Andreza Ribeiro Simioni Open the ORCID record for Andreza Ribeiro Simioni [Opens in a new window]
Alexandro da Silva Abreu
Affiliation:
Organic Synthesis Laboratory, Research and Development Institute—IPD, Vale do Paraíba University, São José dos Campos 12244-000, Brazil
Janicy Arantes Carvalho
Affiliation:
Organic Synthesis Laboratory, Research and Development Institute—IPD, Vale do Paraíba University, São José dos Campos 12244-000, Brazil
Antonio Claudio Tedesco
Affiliation:
Departament of Chemistry, Center of Nanotechnology and Tissue Engineering- Photobiology and Photomedicine (CNET), University of São Paulo, Ribeirão Preto, SP 14040-901, Brazil
Milton Beltrame Junior
Affiliation:
Organic Synthesis Laboratory, Research and Development Institute—IPD, Vale do Paraíba University, São José dos Campos 12244-000, Brazil
Andreza Ribeiro Simioni*
Affiliation:
Organic Synthesis Laboratory, Research and Development Institute—IPD, Vale do Paraíba University, São José dos Campos 12244-000, Brazil
*
a)Address all correspondence to this author. e-mail: simioni@univap.br
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Abstract

This paper describes the fabrication of polyelectrolyte microspheres using porous manganese carbonate as a sacrificial template for entrapped photosensitizer (PS) drugs for photodynamic therapy application. These particles were used as templates for polyelectrolyte layer-by-layer assembly (Lbl) of two oppositely charged polyelectrolytes: poly(styrene sulfonate) and poly(allylamine hydrochloride). When the polyelectrolyte multilayer shell was built around the MnCO3 core by the Lbl protocol and the core was extracted with acid solution and EDTA, the resultant assembly consisted of hollow polyelectrolyte spheres. Chloroaluminum phthalocyanine was chosen as the model drug to load into the hollow spheres. All the spectroscopic results presented showed excellent photophysical parameters of the studied drug. The fabrication of polyelectrolyte hollow spheres can be used as an optimal medium for a variety of bioactive materials, which can also be encapsulated by the proposed method.

Keywords

manganese carbonatelayer-by-layerphotodynamic therapypolyelectrolytephotosensitizer

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Type
Article
Information
Journal of Materials Research , Volume 34 , Issue 8 , 29 April 2019 , pp. 1353 - 1362
Copyright
Copyright © Materials Research Society 2019 

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