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Amino acid–intercalated layered double hydroxide core @ ordered porous silica shell as drug carriers: Design and applications

Published online by Cambridge University Press:  07 November 2019

Jianqiang Wang Open the ORCID record for Jianqiang Wang [Opens in a new window] ,
Wenpei Zhang ,
Lifeng Hao ,
Jun Sun ,
Wenqi Zhang ,
Cheng Guo ,
Yuhan Mu ,
Weiting Ji ,
Caiyuan Yu  and
Fangming Yuan
Jianqiang Wang*
Affiliation:
School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, Jiangsu 211816, China
Wenpei Zhang
Affiliation:
School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, Jiangsu 211816, China
Lifeng Hao*
Affiliation:
Department of Engineering, Qiuzhen School, Huzhou University, Huzhou, Zhejiang 313000, China
Jun Sun
Affiliation:
School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, Jiangsu 211816, China
Wenqi Zhang
Affiliation:
School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, Jiangsu 211816, China
Cheng Guo
Affiliation:
School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, Jiangsu 211816, China
Yuhan Mu
Affiliation:
College of Food Science and Light Industry, Nanjing Tech University, Nanjing, Jiangsu 211816, China
Weiting Ji
Affiliation:
College of Food Science and Light Industry, Nanjing Tech University, Nanjing, Jiangsu 211816, China
Caiyuan Yu
Affiliation:
College of Food Science and Light Industry, Nanjing Tech University, Nanjing, Jiangsu 211816, China
Fangming Yuan
Affiliation:
College of Food Science and Light Industry, Nanjing Tech University, Nanjing, Jiangsu 211816, China
*
a)Address all correspondence to these authors. e-mail: jqwang@njtech.edu.cn
b)e-mail: 02578@zjhu.edu.cn
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Abstract

A nanoparticle-based drug delivery system is first established by mesoporous silica encapsulating amino acid–intercalated layered double hydroxide (LDH) to construct nanocomposites AA-LDH@MS. The amino acids including phenylalanine (Phe) and histidine (His) with aromatic groups are intercalated into LDH as the cores Phe-LDH and His-LDH. These nanocomposites AA-LDH@MS display multispaces of the interlayer spaces of LDH and porous channels of mesoporous silica to load drugs. Moreover, amino acid molecules provide the interaction sites to improve effectively loading amounts of drugs. 5-Fluorouracil (5-FU) is used as the cargo molecules to observe the delivery in vitro. The results indicate that the maximum loading amounts of drugs are up to 392 mg/g at 60 °C for 12 h in the nanocomposite Phe-LDH@MS. All the nanocomposites exhibit the sustained release of 5-FU at pH 4 and pH 7.4. The Korsmeyer–Peppas model is used to fit the kinetic plot of the drug release in vitro, which concludes that 5-FU release from AA-LDH@MS belongs to Fickian diffusion.

Keywords

core–shelldrug deliverylayered double hydroxideamino acidspH responsive
Type
Article
Information
Journal of Materials Research , Volume 34 , Issue 22 , 28 November 2019 , pp. 3747 - 3756
Copyright
Copyright © Materials Research Society 2019 

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