No CrossRef data available.
Article contents
Immediate and long-term efficacy of persistent throat symptoms to gastric inlet patch ablation
Published online by Cambridge University Press: 24 July 2025
Abstract
Objective
Efficacy of gastric inlet patch (GIP) ablation using argon plasma coagulation (APC) for patients presenting with persistent throat symptoms was evaluated.
Methods
Retrospective observational study from a single university hospital. Consecutive patients who had GIP ablation for persistent throat symptoms between 01/10/2018-31/10/2023 were reviewed and patients who met all of the set inclusion and exclusion criteria were included in this study for analysis.
Results
50% (n = 18/36) of patients responded to APC ablation (median follow-up 3 months) with their post-ablation GETS score decreasing by 30-100%. Long-term follow-up results could be obtained from 22 patients (n = 22/36) and 75% (n = 9/12) had their clinical effects maintained (median follow-up 4.5 years; range 2.7–5.8 years).
Conclusion
GIP ablation can be a very effective treatment for patients with persistent throat symptoms with its therapeutic effects long-lasting. Future studies should focus on evaluating the optimal patient selection process for GIP ablation for persistent throat symptoms.
Information
- Type
- Main Article
- Information
- Copyright
- © The Author(s), 2025. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED.
References
O’Hara, J, Stocken, DD, Watson, GC, Fouweather, T, McGlashan, J, MacKenzie, K, et al. Use of proton pump inhibitors to treat persistent throat symptoms: multicentre, double blind, randomised, placebo controlled trial. BMJ 2021;372:m490310.1136/bmj.m4903CrossRefGoogle ScholarPubMed
Meining, A, Bajbouj, M. Gastric inlet patches in the cervical esophagus: what they are, what they cause, and how they can be treated. Gastrointest Endosc 2016;84:1027–102910.1016/j.gie.2016.08.012CrossRefGoogle ScholarPubMed
Rusu, R, Ishaq, S, Wong, T, Dunn, JM. Cervical inlet patch: new insights into diagnosis and endoscopic therapy. Frontline Gastroenterol 2018;9:214–22010.1136/flgastro-2017-100855CrossRefGoogle ScholarPubMed
Meining, A, Bajbouj, M, Preeg, M, Reichenberger, J, Kassem, AM, Huber, W, et al. Argon plasma ablation of gastric inlet patches in the cervical esophagus may alleviate globus sensation: a pilot trial. Endoscopy 2006;38:566–57010.1055/s-2006-925362CrossRefGoogle ScholarPubMed
Dunn, JM, Sui, G, Anggiansah, A, Wong, T. Radiofrequency ablation of symptomatic cervical inlet patch using a through-the-scope device: a pilot study. Gastrointest Endosc 2016;84:1022-1026.e210.1016/j.gie.2016.06.037CrossRefGoogle ScholarPubMed
Bajbouj, M, Becker, V, Eckel, F, Miehlke, S, Pech, O, Prinz, C, et al. Argon plasma coagulation of cervical heterotopic gastric mucosa as an alternative treatment for globus sensations. Gastroenterology 2009;137:440–44410.1053/j.gastro.2009.04.053CrossRefGoogle Scholar
Deary, IJ, Wilson, JA, Harris, MB, MacDougall, G. Globus pharyngis: development of a symptom assessment scale. J Psychosom Res 1995;39:203–21310.1016/0022-3999(94)00104-DCrossRefGoogle ScholarPubMed
Klare, P, Meining, A, von Delius, S, Wolf, P, Konukiewitz, B, Schmid, RM, et al. Argon plasma coagulation of gastric inlet patches for the treatment of globus sensation: it is an effective therapy in the long term. Digestion 2013;88:165–17110.1159/000355274CrossRefGoogle Scholar
Frieling, T, Kuhlbusch-Zicklam, R, Weingardt, C, Heise, J, Kreysel, C, Blank, M, et al. Clinical impact of esophageal function tests and argon plasma coagulation in heterotopic gastric mucosa of the esophagus and extraesophageal reflux symptoms - a prospective study. Z Gastroenterol 2015;53:101–107Google ScholarPubMed
Alberty, JB, Chanis, R, Khoshoo, V. Symptomatic gastric inlet patches in children treated with argon plasma coagulation: a case series. J Interv Gastroenterol 2012;2:91–9310.4161/jig.22207CrossRefGoogle ScholarPubMed
Di Nardo, G, Cremon, C, Bertelli, L, Oliva, S, De Giorgio, R, Pagano, N. Esophageal Inlet Patch: An Under-Recognized Cause of Symptoms in Children. J Pediatr 2016;176:99-104.e110.1016/j.jpeds.2016.05.059CrossRefGoogle ScholarPubMed
Hussein, M, Rusu, R, Boger, P, Cordle, J, Zeki, S, Wong, T, et al. P265 Randomised controlled trial of barrx radiofrequency ablation through-the-scope device versus sham for symptomatic cervical (gastric) inlet patch – interim analysis. Gut 2024;73:A206-A207Google Scholar
Weickert, U, Wolf, A, Schröder, C, Autschbach, F, Vollmer, H. Frequency, histopathological findings, and clinical significance of cervical heterotopic gastric mucosa (gastric inlet patch): a prospective study in 300 patients. Dis Esophagus 2011;24:63–6810.1111/j.1442-2050.2010.01091.xCrossRefGoogle Scholar
Alagozlu, H, Simsek, Z, Unal, S, Cindoruk, M, Dumlu, S, Dursun, A. Is there an association between Helicobacter pylori in the inlet patch and globus sensation? World J Gastroenterol 2010;16:42–47Google ScholarPubMed
Beg, S, Ragunath, K, Wyman, A, Banks, M, Trudgill, N, Pritchard, DM, et al. Quality standards in upper gastrointestinal endoscopy: a position statement of the British Society of Gastroenterology (BSG) and Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS). Gut 2017;66:1886–189910.1136/gutjnl-2017-314109CrossRefGoogle Scholar
DeMeester, TR, Wang, CI, Wernly, JA, Pellegrini, CA, Little, AG, Klementschitsch, P, et al. Technique, indications, and clinical use of 24 hour esophageal pH monitoring. J Thorac Cardiovasc Surg 1980;79:656–67010.1016/S0022-5223(19)37879-1CrossRefGoogle ScholarPubMed
Neto, RML, Herbella, FAM, Schlottmann, F, Patti, MG. Does DeMeester score still define GERD? Dis Esophagus 2019;32:doy11810.1093/dote/doy118CrossRefGoogle ScholarPubMed