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Can vocal process granuloma location forecast the efficacy of anti-reflux treatment?

Published online by Cambridge University Press:  09 February 2022

J Ding  and
Z Lou Open the ORCID record for Z Lou [Opens in a new window]
J Ding
Affiliation:
Department of Surgery, Yiwu Central Hospital, Yiwu city, China
Z Lou*
Affiliation:
Department of Otorhinolaryngology, Yiwu Central Hospital, Yiwu city, China
*
Author for correspondence: Dr Z Lou, Department of Otorhinolaryngology, Yiwu Central Hospital, 699 Jiangdong road, Yiwu 322000, China E-mail: louzhengcai@163.com
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Abstract

Objective

The objective of this study was to evaluate the efficacy of anti-reflux therapy on the idiopathic vocal process granulomas.

Method

This was a prospective case series study. The patients with vocal process granulomas who met the inclusion criteria were analysed. Proton pump inhibitors and vocal hygiene education were conducted for 8–20 weeks.

Results

Of the 16 patients with vocal process granulomas, 5 (31.25 per cent) patients achieved complete remission. The complete remission rate of granulomas was not significantly related to age (p = 1.000), sex (p = 0.296), side (p = 0.299), position (p = 0.100), endoscopic morphology (p = 0.263) or proton pump inhibitor treatment course (p = 0.543) but was significantly associated with granuloma location (p = 0.001) and granuloma size (p = 0.012).

Conclusion

Granulomas in the vocal cord and the margin of the vocal process had an excellent response to proton pump inhibitors, but granulomas on the surface of vocal process and arytenoid cartilage body had little response to proton pump inhibitors. The prolonged period of proton pump inhibitor treatment did not increase the complete remission rate of vocal process granulomas.

Keywords

Vocal FoldArytenoid CartilageProton Pump Inhibitors
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 137 , Issue 2 , February 2023 , pp. 178 - 185
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr Z Lou takes responsibility for the integrity of the content of the paper

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