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Immune monitoring of Trichuris suis egg therapy in multiple sclerosis patients

Published online by Cambridge University Press:  15 August 2011

F. Benzel ,
H. Erdur ,
S. Kohler ,
M. Frentsch ,
A. Thiel ,
L. Harms ,
K.-P. Wandinger  and
B. Rosche
F. Benzel
Affiliation:
Department of Neurology & Experimental Neurology, Charité-Universitätsmedizin Berlin, Germany
H. Erdur
Affiliation:
Department of Neurology & Experimental Neurology, Charité-Universitätsmedizin Berlin, Germany
S. Kohler
Affiliation:
Department of Neurology & Experimental Neurology, Charité-Universitätsmedizin Berlin, Germany Berlin-Brandenburg Center of Regenerative Therapies, Charité-Universitätsmedizin Berlin, Germany
M. Frentsch
Affiliation:
Berlin-Brandenburg Center of Regenerative Therapies, Charité-Universitätsmedizin Berlin, Germany
A. Thiel
Affiliation:
Berlin-Brandenburg Center of Regenerative Therapies, Charité-Universitätsmedizin Berlin, Germany
L. Harms
Affiliation:
Department of Neurology & Experimental Neurology, Charité-Universitätsmedizin Berlin, Germany
K.-P. Wandinger
Affiliation:
Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Eppendorf, Hamburg, Germany Institute for Experimental Immunology, affiliated with Euroimmun, Luebeck, Germany
B. Rosche*
Affiliation:
Department of Neurology & Experimental Neurology, Charité-Universitätsmedizin Berlin, Germany
*
*Fax: 0049-30 450560912 E-mail: berit.rosche@charite.de
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Abstract

Initial clinical trials using Trichuris suis eggs (TSO) in autoimmune diseases such as inflammatory bowel disease, revealed a striking suppressive effect on the autoimmune response. Here, we analysed the effect of TSO therapy on the course of multiple sclerosis (MS), as a Th1/Th17-associated autoimmune disease. Different immunological parameters in four patients with secondary progressive MS were surveyed during a 6-month therapy with TSO, focusing on the modulation of T-cell Th1–Th2 balance as well as on the innate immune response. We are able to show a slight downregulation of the Th1-associated cytokine pattern, especially relevant in interleukin (IL)-2 (P < 0.05 after 2 months of therapy), with a temporary increase of Th2-associated cytokines such as IL-4. Furthermore, mild eosinophily and changes in CD4+ and CD8+T cells and natural killer (NK) CD56 bright cell numbers were observed. The findings observed in this group of patients suggest that TSO therapy has a moderate immunomodulatory impact in MS.

Type
Research Papers
Information
Journal of Helminthology , Volume 86 , Issue 3 , September 2012 , pp. 339 - 347
Copyright
Copyright © Cambridge University Press 2011

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