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Establishment of the early-life microbiome: a DOHaD perspective

Part of: DOHaD ANZ Conference 2018: Genes, Environment and Evolution

Published online by Cambridge University Press:  11 October 2019

Lisa F. Stinson Open the ORCID record for Lisa F. Stinson [Opens in a new window]
Lisa F. Stinson*
Affiliation:
Division of Obstetrics and Gynaecology, Faculty of Health & Medical Sciences, The University of Western Australia, Perth, WA, Australia
*
Address for correspondence: Lisa F. Stinson, Department of Obstetrics and Gynaecology, The University of Western Australia, 374 Bagot Rd, Subiaco, WA 6008, Australia. Email: lisa.stinson@uwa.edu.au
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Abstract

The human microbiome plays a number of critical roles in host physiology. Evidence from longitudinal cohort studies and animal models strongly supports the theory that maldevelopment of the microbiome in early life can programme later-life disease. The early-life microbiome develops in a clear stepwise manner over the first 3 years of life. During this highly dynamic time, insults such as antibiotic use and formula feeding can adversely affect the composition and temporal development of the microbiome. Such experiences predispose infants for the development of chronic health conditions later in life. This review highlights key factors that disrupt the early-life microbiome and highlights major non-communicable diseases which are underpinned by early-life dysbiosis.

Keywords

maternal microbiomeearly-life microbiomenon-communicable diseasesantibioticsbreastfeeding

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Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 11 , Issue 3 , June 2020 , pp. 201 - 210
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019

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