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Association of the CACNA2D1 gene with milk yield and milk quality traits in Holstein cattle

Published online by Cambridge University Press:  19 May 2025

Fadime Daldaban Open the ORCID record for Fadime Daldaban [Opens in a new window] ,
Jale Metin Kıyıcı ,
Bilal Akyüz ,
Esma Gamze Aksel ,
Mahmut Kaliber ,
Mehmet Ulaş Çınar Open the ORCID record for Mehmet Ulaş Çınar [Opens in a new window]  and
Korhan Arslan
Fadime Daldaban*
Affiliation:
Department of Genetics, Faculty of Veterinary Medicine, Erciyes University, 38280, Kayseri, Türkiye
Jale Metin Kıyıcı
Affiliation:
Department of Animal Science, Faculty of Agriculture, Erciyes University, 38280, Kayseri, Türkiye
Bilal Akyüz
Affiliation:
Department of Genetics, Faculty of Veterinary Medicine, Erciyes University, 38280, Kayseri, Türkiye
Esma Gamze Aksel
Affiliation:
Department of Genetics, Faculty of Veterinary Medicine, Erciyes University, 38280, Kayseri, Türkiye
Mahmut Kaliber
Affiliation:
Department of Animal Science, Faculty of Agriculture, Erciyes University, 38280, Kayseri, Türkiye
Mehmet Ulaş Çınar
Affiliation:
Department of Animal Science, Faculty of Agriculture, Erciyes University, 38280, Kayseri, Türkiye Department of Veterinary Microbiology & Pathology, Washington State University, Pullman, WA, 99164, USA
Korhan Arslan
Affiliation:
Department of Genetics, Faculty of Veterinary Medicine, Erciyes University, 38280, Kayseri, Türkiye
*
Corresponding author: Fadime Daldaban; Email: fadimeozdemir@erciyes.edu.tr
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Abstract

The aim of this study was to investigate the association of the rs43389227, rs43390124 and rs482883241 single-nucleotide polymorphisms (SNPs) of the bovine calcium channel, voltage-dependent, alpha-2/delta subunit 1 (CACNA2D1) gene with milk yield and quality traits in Holstein cattle. For this purpose, 166 Holstein dairy cows were genotyped for these three SNPs. Correlation analyses showed that the rs43389227 SNP was associated with 305-day milk yield (P < 0.05). Besides, rs43390124 SNP was found to be associated not only with 305-day milk yield but also with milk fat, milk quality traits, somatic cell score, electrical conductivity and pH (P < 0.05). The results of this study suggest that the rs43389227 and rs43390124 SNPs could be used in breeding for the improvement of milk yield and milk quality in cattle. Furthermore, based on its association with mastitis related traits, the rs43390124 SNP was considered as a potential indicator of mastitis susceptibility.

Keywords

Animal breedingmastitismilk qualitymilk yield
Type
Research Article
Information
Journal of Dairy Research , Volume 91 , Issue 4 , November 2024 , pp. 373 - 377
Copyright
Copyright © The Author(s), 2025. Published by Cambridge University Press on behalf of Hannah Dairy Research Foundation

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