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Some biochemical and hormonal aspects of experimental ovine pregnancy toxaemia

Published online by Cambridge University Press:  27 March 2009

N. Saba ,
K. N. Burns ,
N. F. Cunningham ,
C. Nancy Hebert  and
D. S. P. Patterson
N. Saba
Affiliation:
Central Veterinary Laboratory, Ministry of Agriculture, Fisheries & Food, Weybridge, Surrey
K. N. Burns
Affiliation:
Central Veterinary Laboratory, Ministry of Agriculture, Fisheries & Food, Weybridge, Surrey
N. F. Cunningham
Affiliation:
Central Veterinary Laboratory, Ministry of Agriculture, Fisheries & Food, Weybridge, Surrey
C. Nancy Hebert
Affiliation:
Central Veterinary Laboratory, Ministry of Agriculture, Fisheries & Food, Weybridge, Surrey
D. S. P. Patterson
Affiliation:
Central Veterinary Laboratory, Ministry of Agriculture, Fisheries & Food, Weybridge, Surrey
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Extract

1. Some of the effects of stress, fasting and ACTH injections in pregnant ewes were investigated.

2. A 6-day fast produced a relatively mild hypoglycaemia and hyperketonaemia without inducing pregnancy toxaemia.

3. Stress of transport produced an immediate slight rise in plasma cortisol; 4 hr. later the plasma cortisol had returned to the pre-stress levels.

4. A combination of stress and fasting produced severe hypoglycaemia, hyperketonaemia and subacute pregnancy toxaemia, but there was no increase in plasma cortisol levels.

5. Daily injections of ACTH resulted in a fourfold increase in plasma cortisol and prevented the development of hypoglycaemia, severe hyperketonaemia, and pregnancy toxaemia in pregnant ewes subjected to stress and fasting.

6. Changes in plasma concentrations of NEFA, urea, proteins, catecholamines and insulin were also investigated.

Type
Research Article
Information
The Journal of Agricultural Science , Volume 67 , Issue 1 , August 1966 , pp. 129 - 138
Copyright
Copyright © Cambridge University Press 1966

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