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A novel 28-bp indel in IGF1R gene associated with growth traits across four Chinese cattle breeds

Published online by Cambridge University Press:  01 March 2022

Jia Tang Open the ORCID record for Jia Tang [Opens in a new window] ,
Yilei Ma ,
Yu Yang ,
Xiaojun Jiang ,
Longping Li ,
Xianyong Lan ,
Enliang Song ,
Chuzhao Lei ,
Xin Wang  and
Hong Chen Open the ORCID record for Hong Chen [Opens in a new window]
Jia Tang
Affiliation:
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China
Yilei Ma
Affiliation:
Shaanxi Agricultural and Animal Husbandry Good Seed Farm, Fufeng, Shaanxi722203, China
Yu Yang
Affiliation:
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China
Xiaojun Jiang
Affiliation:
Shaanxi Agricultural and Animal Husbandry Good Seed Farm, Fufeng, Shaanxi722203, China
Longping Li
Affiliation:
College of Life Science, Yulin University, Yulin, Shaanxi719000, China
Xianyong Lan
Affiliation:
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China
Enliang Song
Affiliation:
Institute of Animal Husbandry and Veterinary, Shandong Academy of Agricultural Sciences, Jinan, Shandong250100, China
Chuzhao Lei
Affiliation:
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China
Xin Wang*
Affiliation:
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China
Hong Chen*
Affiliation:
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China College of Life Science, Yulin University, Yulin, Shaanxi719000, China
*
Author for correspondence: Xin Wang, E-mail: wxwza@126.com; Hong Chen, E-mail: chenhong1212@263.net
Author for correspondence: Xin Wang, E-mail: wxwza@126.com; Hong Chen, E-mail: chenhong1212@263.net
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Abstract

Insulin-like growth factor 1 receptor (IGF1R) is a cell surface receptor, belonging to the tyrosine kinase receptor superfamily. IGF1R plays a role not only in normal cell development but also in malignant transformation, which has become a candidate therapeutic target for the treatment of human cancer. This study aimed to explore insertions and deletions (indels) in IGF1R gene and investigate their association with growth traits in four Chinese cattle breeds (Xianan cattle, Jinnan cattle, Qinchuan cattle and Nanyang cattle). The current paper identified a 28-bp indel by polymerase chain reaction within IGF1R gene. The analysis showed that there was a significant correlation between the locus and the hucklebone width of Nanyang cattle in four periods, in which it was highly correlated at 6, 12 and 18 months. At the age of 6 months, it was also significantly correlated with body height, body weight and body length. Association analysis showed that the locus in Jinnan cattle was extremely significantly correlated with body slanting length and body weight, and significantly correlated with chest circumference. There was no significant correlation between this locus and growth traits of Xianan cattle and Qinchuan cattle. The detected indel in the IGF1R gene was significantly associated with growth traits in Jinnan and Nanyang cattle, and could be used as a molecular marker for growth trait selection.

Keywords

Insertion/deletionbody size databovineinsulin-like growth factor 1 receptor
Type
Animal Research Paper
Information
The Journal of Agricultural Science , Volume 159 , Issue 9-10 , November 2021 , pp. 762 - 768
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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Footnotes

*

These authors contributed equally to this work

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