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Patient-reported outcomes using a wearable cardioverter-defibrillator: results from a systematic review

Published online by Cambridge University Press:  06 January 2023

Pamela Aidelsburger Open the ORCID record for Pamela Aidelsburger [Opens in a new window] ,
Janine Seyed-Ghaemi  and
Diana Bonderman
Pamela Aidelsburger*
Affiliation:
CAREM GmbH, Königsdorf, Germany
Janine Seyed-Ghaemi
Affiliation:
CAREM GmbH, Königsdorf, Germany
Diana Bonderman
Affiliation:
Medical University of Vienna, Vienna, Austria Favoriten Clinic, Vienna, Austria
*
*Author for correspondence: Pamela Aidelsburger, E-mail: p.aidelsburger@carem.de
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Abstract

Objectives

The aim of this study was to assess the effect of the wearable cardioverter-defibrillator (WCD) on patient-reported outcomes (PRO) in adult patients with high risk for sudden cardiac arrest.

Methods

We performed a systematic literature search in Medline (via PubMed) and Cochrane Library in February 2022 and included studies with a study population ≥18 years and prescribed WCD. PRO include health-related quality of life (QoL), symptoms, utilities, or satisfaction ratings. Study selection was done by two reviewers independently using predefined inclusion and exclusion criteria. Quality assessment of studies as well as data extraction was performed by one author and approved by a second author. Results of the included studies are presented quantitatively.

Results

One randomized controlled trial (RCT), one comparative non-randomized trial, and three single-arm trials were included. QoL was assessed in four studies, but with different assessment tools. One study additionally evaluated the change in depressive symptoms and anxiety and one study focused on acceptability of WCD but evaluated items that are closely related to QoL. Results of the RCT show no statistically significant difference in QoL assessed by SF-36 and EQ-5D comparing WCD and Guideline-Directed Medical Therapy (GDMT) versus GDMT alone. One comparative study reports an improvement in depressive symptoms and anxiety within groups but no significant difference between groups. Further, one single-arm study reported improvement in QoL between baseline and day 90 and day 180.

Conclusions

The available evidence demonstrates that the usage of WCD is not affecting PRO, like QoL, depressive symptoms or anxiety negatively.

Keywords

wearable cardioverter defibrillatorWCDsudden cardiac arrestpatient-reported outcomesPRO
Type
Assessment
Information
International Journal of Technology Assessment in Health Care , Volume 39 , Issue 1 , 2023 , e1
Copyright
© The Author(s), 2023. Published by Cambridge University Press

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