Hostname: page-component-5447f9dfdb-9hml6 Total loading time: 0 Render date: 2025-07-29T08:34:44.097Z Has data issue: false hasContentIssue false
  • English
  • Français

Use of Active Surveillance Cultures to Detect Asymptomatic Colonization With Carbapenem-Resistant Klebsiella pneumoniae in Intensive Care Unit Patients

Published online by Cambridge University Press:  02 January 2015

David Calfee  and
Stephen G. Jenkins
David Calfee*
Affiliation:
Department of Medicine, Mount Sinai School of Medicine, New York, New York
Stephen G. Jenkins
Affiliation:
Department of Pathology, Weill Cornell Medical College, New York, New York
*
Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1151, New York, NY 10029 (david.calfee@mountsinai.org)
Get access Rights & Permissions [Opens in a new window]

Abstract

Carbapenem-resistant Klebsiella pneumoniae is emerging as a significant healthcare-associated pathogen. Clinical cultures detect only a fraction of the colonized population, and patients with asymptomatic colonization are at risk of invasive infection. Additional study of the impact of detection of asymptomatic colonization on subsequent infection and transmission is needed.

Information

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 29 , Issue 10 , October 2008 , pp. 966 - 968
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1.Bradford, P, Bratu, S, Urban, C, et al.Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 B-lactamases in New York City. Clin Infect Dis 2004;39:55–60.CrossRefGoogle Scholar
2.Bratu, S, Landman, D, Haag, R, et al.Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium. Arch Intern Med 2005;165:1430–1435.CrossRefGoogle ScholarPubMed
3.Bratu, S, Mooty, M, Nichani, S, et al.Emergence of KPC-possessing Klebsiella pneumoniae in Brooklyn, New York: epidemiology and recommendations for detection. Antimicrob Agents Chemother 2005;49:3018–3020.Google Scholar
4.Schwaber, M, Klarfeld-Lidji, S, Navon-Venezia, S, Schwartz, D, Leavitt, A, Carmeli, Y. Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults, and effect of acquisition on mortality. Antimicrob Agents Chemother 2008;52:1028–33.CrossRefGoogle ScholarPubMed
5.Kuhar, D, Calfee, D. Risk factors for colonization and/or infection with carbapenem-resistant Klebsiella pneumoniae (CRKP). In: Program and abstracts of the 17th Annual Scientific Meeting of the Society for Healthcare Epidemiology of America; 2007; Baltimore, MD. Alexandria, VA: Society for Healthcare Epidemiology of America; 2007:130. Abstract 250.Google Scholar
6.Falagas, M, Rafailidis, P, Kofteridis, D, et al.Risk factors of carbapenem-resistant Klebsiella pneumoniae infections: a matched case-control study. J Antimicrob Chemother 2007;60:1124–1130.CrossRefGoogle ScholarPubMed
7.Patel, G, Huprikar, S, Jenkins, S, Calfee, D. Carbapenem-resistant Klebsiella pneumoniae: risk factors and mortality. In: Program and abstracts of the 45th Annual Meeting of the Infectious Diseases Society of America; October 2007; San Diego, CA. Arlington, VA: Infectious Diseases Society of America; 2007:59. Abstract 563.Google Scholar
8.Bratu, S, Landman, D, Alam, M, Tolentino, E, Quale, J. Detection of KPC carbapenem-hydrolyzing enzymes in Enterobacter spp. from Brooklyn, New York. Antimicrob Agents Chemother 2005;49:776–778.Google Scholar
9.Bratu, S, Brooks, S, Burney, S, et al.Detection and spread of Escherichia coli possessing the plasmid-borne carbapenemase KPC-2 in Brooklyn, New York. Clin Infect Dis 2007;44:972–975.Google Scholar
10.Clinical Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibilities testing: 16th informational supplement. CLSI document. Wayne, PA: CLSI, 2006:M100–S16.Google Scholar
11.Landman, D, Salvani, J, Bratu, S, Quale, J. Evaluation of techniques for detection of carbapenem-resistant Klebsiella pneumoniae in stool surveillance cultures. J Clin Microbiol 2005;43:5639–5641.Google Scholar