Hostname: page-component-68c7f8b79f-fcrnt Total loading time: 0 Render date: 2025-12-20T09:39:47.620Z Has data issue: false hasContentIssue false

Nosocomially Acquired Pseudomonas cepacia Infection in Patients with Cystic Fibrosis

Published online by Cambridge University Press:  21 June 2016

Ofelia C. Tablan*
Affiliation:
Centers for Disease Control and Prevention, Atlanta, Georgia
*
Centers for Disease Control and Prevention, Investigation and Prevention Branch, 1600 Clifton Rd., NE, Bldg. 3, Rm. B-49, Mailstop A-07, Atlanta, GA 30333
Rights & Permissions [Opens in a new window]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'

Information

Type
Editorial
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1993 

References

1. Isles, A, Maclusky, I, Corey, M, et al. Pseudomonas cepacia infection in cystic fibrosis patients: an emerging problem. J Pediatr. 1984;104:206210.Google Scholar
2. Thomassen, MJ, Demko, CA, Klinger, JD, Stern, RC. Pseudomonas cepacia colonization among patients with cystic fibrosis. A new opportunist. Am Rev Hespir Dis. 1985;131:791796.Google Scholar
3. Tablan, OC, Chorba, TL, Schidlow, DV, et al. Pseudomonas cepacia colonization in patients with cystic fibrosis: Risk factors and clinical outcome. J Pediatr. 1985;107:382387.Google Scholar
4. Simmonds, EJ, Conway, SP, Ghoneim, ATM, Ross, H, Littlewood, JM. Pseudomonas cepacia: a new pathogen in patients with cystic fibrosis referred to a large centre in the United Kingdom. Arch Dis Child. 1990;655:874877.Google Scholar
5. Gladman, G, Connor, PJ, Williams, RF, David, TJ. Controlled study of Pseudomonas cepacia and Pseudomonas maltophilia in cystic fibrosis. Arch Dis Child. 1992;67:192195.Google Scholar
6. Govan, JRW, Glass, S. The microbiology and therapy of cystic fibrosis lung infections. Rev Med Microbiol. 1990;1:1928.Google Scholar
7. Corey, M, Allison, L, Prober, C, et al. Sputum bacteriology in patients with cystic fibrosis in a Toronto hospital during 1970-1981. J Infect Dis. 1984;149:283.Google Scholar
8. Saijan, US, Corey, M, Karmali, MA, Forstner, JE Binding of Pseudomonas cepacia to normal human intestinal mucin and respiratory mucin from patients with cystic fibrosis. J Clin Investig. 1992;89:648656.Google Scholar
9. Tablan, OC, Martone, WJ, Doershuk, CF, et al. Risk factors an outcome associated with Pseudomonas cepacia colonization of the respiratory tract of patients with cystic fibrosis. Chest. 1987;91:527533.Google Scholar
10. Tablan, OC, Carson, LA, Cusick, LB, Bland, LA, Martone, WJ. Use of selective media in isolating Pseudomonas cepacia from simulated sputum specimens of cystic fibrosis patients: Results of laboratory proficiency tests. J Clin Microbial. 1987;25:485487.Google Scholar
11. Hardy, KA, McGowan, KL, Fischer, MC, Schidlow, DV. Pseudomoms cepacia in the hospital setting: Lack of transmission between cystic fibrosis patients. J Pediatr. 1986;109:5154.Google Scholar
12. Gessner, AR, Mortensen, JE. Pathogenic factors of Pseudomonas cepacia isolates from patients with cystic fibrosis. J Med Microbiol. 1990;33:115120.Google Scholar
13. LiPuma, JJ, Mortensen, JE, Dasen, SE, et al. Ribotype analysis of Pseudomonas cepacia from cystic fibrosis treatment centers. J Pediatr. 1988;113:859862.Google Scholar
14. LiPuma, JJ, Fisher, K, Dasen, SE, Mortensen, JE, Stall, TL. Ribotype stability of serial pulmonary isolates of Pseudomonas cepacia . J Infect Dis. 1991;164:133136.Google Scholar
15. Fitzsimmons SA Personal communication with author. Also unpublished date from the Centers for Disease Control and Prevention, Atlanta, GA.Google Scholar
16. Hoiby, N. Microbiology of lung infections in cystic fibrosis patients. Acta Faediatr Scand. 1982;301 (Suppl):3354.Google Scholar
17. Hoiby, N, Flensborg, EW, Beck, B, Friis, B, Jacobsen, JV, Jacobsen, L. Pseudomonas aeruginosa infection in cystic fibrosis. Diagnostic and prognostic significance of Pseudomonas aeruginosa precipitins determined by means of crossed Immunoelectrophoresis. Scand J Respir Dis. 1977;58:6579.Google Scholar
18. Pitcher-Wilmott, RW, Levinsky, RJ, Gordon, I, Turner, MW, Matthew, DJ. Pseudomonas infection, allergy, and cystic fibrosis. Arch Dis Child. 1982;57:582586.Google Scholar
19. Baltimore, RS, Christie, CDC, Smith, GIW. Immunologic localization of Pseudomonas aeruginosa in lungs from patients with cystic fibrosis. Am Rev Respir Dis. 1989;140:16501661.Google Scholar
20. Knohe, JD, Stern, RC, Doershuk, CF, Boat, TF, Matthews, LW. Cystic fibrosis: the prognosis for five year survival. Pediatr Res. 1978;12:676679.Google Scholar
21. Wilmott, RW, Tyson, SL, Matthew, DJ. Cystic fibrosis survival rates. The influences of allergy and Pseudomonas aeruginosa. Am J Dis Child. 1985;139:669671.Google Scholar
22. Henry, RL, Mellis, CM, Petrovic, L. Mucoid Pseudomonas aeruginosa is a marker of poor survival in cystic fibrosis. Fediatr Pulmonol. 1992;12:158161.Google Scholar
23. Conly, JM, Klass, LL, Larson, L, Kennedy, J, Low, DE, Harding, GKM. Pseudomonas cepacia colonization and infection in intensive care units. Can Med Assoc J. 1986;134:363366.Google Scholar
24. Gelbart, SM, Reinhardt, GE Greenlee, HB. Pseudomonas cepacia strains isolated from water reservoirs of unheated nebulizers. J Clin Microbiol. 1976;3:6266.Google Scholar
25. Grieble, HG, Colton, RF, Bird, TJ, Toigo, A, Griffith, LG. Fine particle humidifiers: source of Pseudomonas aeruginosa infections in a respiratory disease unit. N Engl J Med. 1970;282:531535.Google Scholar
26. Martone, WJ, Tablan, OC, Jarvis, WR. The epidemiology of nosocomial epidemic Pseudomonas cepacia infections. Eur J Epidemiol. 1987;3:222232.Google Scholar
27. Martone, WJ, Osterman, CA, Fisher, KA, et al. Pseudomonas cepacia: implications and control of epidemic nosocomial colonization. Rev Infect Dis. 1981;3:708715.Google Scholar
28. Stover, GB, Drake, DR, Montie, TC. Virulence of different pseudomonas species in a burned mouse model: tissue colonization by Pseudomonas cepacia . Infect Immun. 1983;41:10991104.Google Scholar
29. Nakazawa, T, Yamada, Y, Ishibashi, M. Characterization of hemolysin in extracellular products of Pseudomonas cepacia . J Clin Microbiol. 1984;19:291293.Google Scholar
30. McKevitt, AL, Woods, DE. Charcterization of Pseudomonas cepacia isolates from patients with cystic fibrosis. J Clin Microbiol. 1984;19:291293.Google Scholar
31. Vasil, ML, Krieg, DP, Kuhns, JS, et al. Molecular analysis of hemolytic and phospholipase C activities of Pseudomonas cepacia . Infect Immun. 1990;58:40204029.Google Scholar
32. Rosenstein, BJ, Hall, DE. Pneumonia and septicemia due to Pseudomonas cepacia in a patient with cystic fibrosis. Johns Hopkins Med J. 1980;47:188189.Google Scholar
33. Boxerbaum, JF, Klinger, JD. Pseudomonas cepacia bacteremia in cystic fibrosis. Pediatr Res. 1984;18:269A.Google Scholar
34. Tomashefski, JF, Thomassen, Ml. Bruce, MC. Goldberg, HI, Konstan, MW, Stern, RC. Pseudomonas cepacia-associated pneumonia in cystic fibrosis. Relation of clinical features to histopathologic patterns of pneumonia. Arch Pathol Lab Med. 1988;112:166172.Google Scholar
35. Gold, R, Jim, E, Levison, H, et al Ceftazidime alone and in combination in patients with cystic fibrosis: Lack of efficacy in treatment of severe respiratory infections caused by Pseudomonas cepacia . J Antimicrob Chemother. 1983;12(supp A):331336.Google Scholar
36. Fass, RJ, Bamishan, J. In vitro susceptibility of nonfermentative gram-negative bacilli other than Pseudomonas aeruginosa to 32 antimicrobial agents. Rev Infect Dis. 1980;2:841843(abstract).Google Scholar
37. Klinger, JD, Thomassen, MJ. Occurrence and antimicrobial susceptibility of gram-negative nonfermentative bacilli in cystic fibrosis patients. Diagn Microbiol Infect Dis. 1985;3:149158.Google Scholar
38. Thomassen, MJ, Demko, CA, Doershuk, CE Stern, RC, Klinger, JD. Pseudomonas cepacia: Decrease in colonization in cystic fibrosis patients. Am Rev Respir Dis. 1986;134:669671.Google Scholar
39. Millar-Jones, L, Paull, A, Saunders, Z, Goodchild, MC. Transmission of Pseudomonas cepacia among cystic fibrosis patients. Lancet. 1992;340:491.Google Scholar
40. Johanson, WG, Pierce, AK, Sanford, JP. Changing pharyngeal bacterial flora of hospitalized patients. N Engl J Med. 1969;281:11371140.Google Scholar
41. Pegues, DA. Personal communication with author.Google Scholar
42. Johanson, WG, Pierce, AK, Sanford, JP, Thomas, GD. Nosocomial respiratory infections with gram-negati ve bacilli. Ann Intern Med. 1972;77:701706.Google Scholar
43. Craven, DE, Kunches, LM, Kilinsky, V, Lichtenberg, DA, Make, BJ, McCabe, WR. Risk factors for pneumonia and fatality in natients receiving continuous mechanical ventilation. Am Rev Respir Dis. 1986;133:792796.Google Scholar
44. Weinstein, RA, Kabins, SA. Strategies for prevention and control of multiple drug-resistant nosocomial infection. Am J Med. 1981;70:449454.Google Scholar
45. Casewell, M, Phillips, I. Hands as route of transmission for Klebsiella species. Brit Medf. 1977;2:13151317.Google Scholar
46. Tummler, B, Koopman, U, Frothues, D, Weissbredt, H, Steinkamp, G. Hardt, H. Nosocomial acquisition of Pseudomonas aeruginosa by cystic fibrosis patients. J Clin Microbiol. 1991;29:12651267.Google Scholar
47. LiPuma, JJ, Dasen, TD, Nielson, DW, Stern, RC, Stull, TL. Person-to-person transmission of Pseudomonas cepacia between patients with cystic fibrosis. Lancet. 1990:10941096.Google Scholar
48. Nelson, JW, Doherty, CJ Brown, PH, et al. Pseudomonas cepacia in inpatients with cystic fibrosis. Lancet. 1991;338:1525.Google Scholar
49. Garner, JS, Simmons, BP Guideline for isolation precautions in hospitals. Infect Control. 1983;4(supp):245325.Google Scholar
50. Tablan, OC, Martone, WJ, Jarvis, WR. The epidemiology of Pseudomonas cepacia inpatients with cystic fibrosis. Eur J Epidemiol. 1987;3:336342.Google Scholar
51. Conly, JM, Hill, S, Ross, J, Lertzman, J, Louie, TJ. Handwashing practices in an intensive care unit: The effects of an educational program and its relationship to infection rates. Am J Infect Control. 1989;17:330339.Google Scholar
52. Rabkin, CS, Jarvis, WR, Anderson, RL, et al. Pseudomonas cepacia typing systems: collaborative study to assess their potential in epidemiologic investigations. Rev Infect Dis. 1989;11:600607.Google Scholar
53. Anderson, DJ, Kuhns, JS, Vasil, ML, Gerding, DN, Janoff, EN. DNA fingerprinting by pulsed field gel electrophoresis and ribotyping to distinguish Pseudomonas cepaciu isolates from a nosocomial outbreak. J Clin Microbiol. 1991;29:648649.Google Scholar
54. Pierce, AK, Sanford, JP. Bacterial contamination of aerosols. Arch Intern Med. 1973;131:156159.Google Scholar
55. Kuhn, RJ, Lubin, AH, Jones, PR, et al Bacterial contamination of aerosol solutions used to treat cystic fibrosis. Am J Hasp Pharm. 1982;39:308309.Google Scholar
56. Reinarz, JA, Pierce, AK, Mays, BB, Sanford, JR The potential role of inhalation therapy equipment in nosocomial pulmonary infection. J Clin Investig. 1965;44:831839.Google Scholar
57. Pierce, AK, Sanford, JP, Thomas, GD, Leonard, JS. Long-term evaluation of decontamination of inhalation-therapy equipment and the occurrence of necrotizing pneumonia. N Engl J Med. 1970;292:528531.Google Scholar
58. Simmons, BP Wong, ES. Guideline for prevention of nosocomial pneumonia. Infect Control. 1982;3:327333.Google Scholar
59. Garner, JS, Favero, MS. Guideline for handwashing and hospital enviromental control. Infect Control. 1986;7:231242.Google Scholar