Hostname: page-component-54dcc4c588-2bdfx Total loading time: 0 Render date: 2025-10-06T09:35:00.124Z Has data issue: false hasContentIssue false

Economic impact of multiple recurrent Clostridioides difficile infection in a community teaching hospital

Published online by Cambridge University Press:  29 September 2025

Joseph Reilly*
Affiliation:
Department of Clinical Pharmacy, AtlantiCare Regional Medical Center, Pomona, NJ, USA
Gemma Downham
Affiliation:
Department of Patient Safety and Infection Prevention, AtlantiCare Regional Medical Center, Pomona, NJ, USA
Manish Trivedi
Affiliation:
Department of Infectious Diseases, AtlantiCare Regional Medical Center, Pomona, NJ, USA
*
Corresponding author: Joseph Reilly; Email: joreilly@atlanticare.org

Abstract

A retrospective study evaluating the economic impact on a community teaching hospital of 29 patients with multiple Clostridioides difficile infection admissions in a 4-year period showed an estimated net loss of $2,232,997, posing a substantial economic impact on the hospital.

Information

Type
Concise Communication
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

Previous Publication: These data were previously presented at the 56th ASHP Midyear Clinical Meeting and Exhibition; Virtual. December, 2021.

References

Guh, AY, Mu, Y, Winston, LG, et al. Trends in U.S. burden of Clostridioides difficile infection and outcomes. N Engl J Med 2020;382:13201330 10.1056/NEJMoa1910215CrossRefGoogle ScholarPubMed
Finn, E, Andersson, FL, Madin-Warburton, M. Burden of Clostridioides difficile infection (CDI)—a systematic review of the epidemiology of primary and recurrent CDI. BMC Infect Dis 2021;21:456 10.1186/s12879-021-06147-yCrossRefGoogle Scholar
Feuerstadt, P, Theriault, N, Tillotson, G. The burden of CDI in the United States: a multifactorial challenge. BMC Infect Dis 2023;23:132 10.1186/s12879-023-08096-0CrossRefGoogle ScholarPubMed
Centers for Disease Control and Prevention. Antibiotic resistance threats in the united states, 2019; 2019 Google Scholar
Ma, GK, Brensinger, CM, Wu, Q, Lewis, JD. Increasing incidence of multiply recurrent Clostridium difficile infection in the United States. Ann Intern Med 2017;167:152158 10.7326/M16-2733CrossRefGoogle ScholarPubMed
Malone, DC, Armstrong, EP, Gratie, D, Pham, S V, Amin, A. A systematic review of real-world healthcare resource use and costs of Clostridioides difficile infections. Antimicrob Stewardship Healthc Epidemiol 2023;3:e17 10.1017/ash.2022.369CrossRefGoogle Scholar
Johnson, S, Lavergne, V, Skinner, AM, et al. Clinical practice guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 focused update guidelines on management of Clostridioides difficile infection in adults. Clin Infect Dis 2021;73:e1029e1044 10.1093/cid/ciab549CrossRefGoogle Scholar
McDonald, LC, Gerding, DN, Johnson, S, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis 2018;66:e1e48 10.1093/cid/cix1085CrossRefGoogle Scholar
KFF.org. Hospital adjusted expenses per inpatient day. Accessed July 19, 2024. https://www.kff.org/health-costs/state-indicator/expenses-per-inpatient-day/ Google Scholar
Federal Reserve Bank. Consumer Price Index for all urban consumers: medical care in U.S. city average. Accessed July 19, 2024. https://fred.stlouisfed.org/series/CPIMEDSL Google Scholar
Society of Critical Care Medicine. Critical care statistics. Accessed July 19, 2024. https://www.sccm.org/Communications/Critical-Care-Statistics Google Scholar
Zilberberg, MD, Shorr, AF, Jesdale, WM, Tjia, J, Lapane, K. Recurrent Clostridium difficile infection among Medicare patients in nursing homes. Medicine (Baltimore) 2017;96:e6231 10.1097/MD.0000000000006231CrossRefGoogle Scholar
Centers for Medicare and Medicaid Services. FY 2024 IPPS Final Rule Home Page. Accessed August 13, 2024. https://www.cms.gov/medicare/payment/prospective-payment-systems/acute-inpatient-pps/fy-2024-ipps-final-rule-home-page Google Scholar
Rodrigues, R, Barber, GE, Ananthakrishnan, AN. A comprehensive study of costs associated with recurrent Clostridium difficile infection. Infect Control Hosp Epidemiol 2017;38:196202.10.1017/ice.2016.246CrossRefGoogle ScholarPubMed