Hostname: page-component-669899f699-ggqkh Total loading time: 0 Render date: 2025-04-24T14:51:19.273Z Has data issue: false hasContentIssue false
  • English
  • Français

Respiratory Syncytial Virus

Published online by Cambridge University Press:  21 June 2016

John T. Sinnott IV ,
Lindy S. Gilchrist  and
Leighton Ellis
John T. Sinnott IV*
Affiliation:
Division of Infectious and Tropical Diseases, Department of Internal Medicine, University of South Florida College of Medicine
Lindy S. Gilchrist
Affiliation:
University of South Florida College of Medicine
Leighton Ellis
Affiliation:
Department of Pediatrics, University of South Florida College of Medicine
*
Tampa General Hospital, PO Box 1289, Tampa, FL 33601
Get access Rights & Permissions [Opens in a new window]

Extract

Respiratory syncytial virus (RSV) is the most important cause of lower respiratory tract infection in outpatients, as well as the major viral cause of nosocomial illness in pediatric inpatients. Immunity to this common pathogen is short lived and reinfection can occur later in life, even into adulthood. Virtually all children have one infection before 24 months and 50% experience two or more episodes of infection. The attack rate is substantial with about half of all infants in a community becoming ill during the season's first epidemic. About 100,000 children in the US each year become ill enough to require hospitalization, the hospitalization rate being 1411,000 during epidemic periods. In certain locations, RSV accounts for about 45% of hospital admissions for respiratory disease in children under two years of age.

Type
Special Sections
Information
Infection Control & Hospital Epidemiology , Volume 9 , Issue 10 , October 1988 , pp. 465 - 468
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1988

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1. Arditin, , Moshe, , Shulman, : Nosocomial viral infections in neonatal units. Part II. J Noso infect 1988; 5(1):10–20.Google Scholar
2. Hall, CB, Geiman, JM, et al: Respiratory syncytial virus infections within families. N Engl J Med 1976; 294:414–419.CrossRefGoogle ScholarPubMed
3. Glezen, WP: Incidence of respiratory syncytial and parainfluenza type 3 viruses in an urban setting. Pediatr Virol 1987; 2(2):1–7.Google Scholar
4. Hall, CB, Douglas, RG: RSV and influenza. Practical community surveillance. Am J Dis Child 1976; 130:615.10.1001/archpedi.1976.02120070041009CrossRefGoogle ScholarPubMed
5. Kim, HW, Arrobio, JD, Brandt, CD, et al: Epidemiology of RSV infection in Washington DC, I: Importance of the virus in different respiratory tract disease syndromes and temporal distribution of infection. Am J Epidemiol 1973; 98:216–225.CrossRefGoogle Scholar
6. Brandt, CD, Kim, HW, Arrobio, JD, et al: Epidemiology of RSV infection in Washington, DC, III. Composite analysis of eleven consecutive yearly epidemics. Am J Epidemiol 1973; 98:355.CrossRefGoogle Scholar
7. Halstead, DC: Noncultural methods for diagnosing RSV infections. Clin Microbial News 1987; 9(23):181–188.CrossRefGoogle Scholar
8. Hall, CB: RSV, in Mandell, GL, et al (ed): Principles and Practices of Infectious Diseases, ed 2. New York, John Wiley & Sons, 1985, pp 877–888.Google Scholar
9. Hall, CB: Quantitative shedding patterns of RSV in infants. J infect Dis 1975; 132:151–156.CrossRefGoogle Scholar
10. Hall, CB, Douglas, RG, Geiman, JM: Possible transmission by fomites of RSV. J infect Dis 1980; 141(1):98–102.10.1093/infdis/141.1.98CrossRefGoogle Scholar
11. Valenti, WM, Betts, RF, et al: Nosocomial viral infections: II. Guidelines for prevention and control of respiratory- viruses, herpesvirus, and hepatitis viruses. Infect Control 1980; 1(3): 165–178.CrossRefGoogle ScholarPubMed
12. Hall, CB, Douglas, RG Jr, Steinhoff, MC: Infectivity of RSV by various routes of inoculation (abstract). Pediatr Res 1979; 13–14.Google Scholar
13. Murphy, D, Todd, JK, Chao, RK, et al: The use of gowns and masks to control respiratory illnesses in pediatric hospital pesonnel. J Pediatr 1981; 99:746–750.10.1016/S0022-3476(81)80401-5CrossRefGoogle Scholar
14. Gala, CL, Hall, CB, et al: The use of eye-nose goggles to control nosocomial RSV infection. JAMA 1986; 256(19):2706–2708.CrossRefGoogle Scholar
15. Hall, CB, Douglas, RG Jr. et al: Nosocomial RSV infections. N Engl J Med 1975; 293:1343–1346.10.1056/NEJM197512252932604CrossRefGoogle Scholar
16. Leclair, JM, Freeman, J, et al: Prevention of nosocomial RSV infections through compliance with glove and gown isolation precautions. N Engl J Med 1987; 317(6):329–334.CrossRefGoogle ScholarPubMed
17. Frank, AL, Taber, LM. Glezen, WP, et al: Breast feeding and respiratory virus infection. Pediatrics 1982; 70:239–245.10.1542/peds.70.2.239CrossRefGoogle ScholarPubMed
18. Sarkkinen, H, et al: Identification of respiratory virus antigens in middle ear fluids of children with acute otitis media. J Infect Dis 1985; 151:444–445.CrossRefGoogle ScholarPubMed
19. Marks, MI: Diagnosis and management of RSV infectious in a major community/university children's hospital. Pediatr Virol 1988; 3(1):1–7.Google Scholar
20. Simpson, H, Matthews, DJ, et al: Acute respiratory failure in bronchiolitis and pneumonia in infants. Modes of presentation and treatment. Br Med J 1974; 2:632–636.CrossRefGoogle ScholarPubMed
21. Hogg, JC, Williams, J, et al: Age as a factor in the distribution of lower airway conductance and in the pathologic anatomy of obstructive lung disease. N Engl J Med 1970; 282:1283–1287.CrossRefGoogle ScholarPubMed
22. MacDonald, NE: RSV Update: Time to alter your clinical approach? J Respir Dis 1985; 6:11–16.Google Scholar
23. Hall, CB, Kopelman, AE, et al: Neonatal RSV infection. N Engl J Med 1979; 300:393–396.10.1056/NEJM197902223000803CrossRefGoogle Scholar
24. Macklem, PT, Mead, J: Resistance of central and peripheral airways measured by a retrograde catheter. J Appl Physiol 1967; 22:395–401.CrossRefGoogle ScholarPubMed
25. Hall, WJ, Hall, CB, Speers, DM: RSV infection in adults–clinical, virologic and serial pulmonary function studies. Ann Intern Med 1978; 88:203–205.10.7326/0003-4819-88-2-203CrossRefGoogle ScholarPubMed
26. Sinnott, JT, Cullison, JP, et al: RSV Pneumonia in a cardiac transplant patient. J Infect Dis 1988; (In press).Google Scholar
27. Hall, CB, Douglas, KG: Clinically useful method for the isolation of RSV. J Infect Dis 1975; 131:1.CrossRefGoogle Scholar
28. Bruhn, FW, Yeager, AS: RSV in early infancy circulating antibody and the severity of infection. Am J Dis Child 1977; 131:145.CrossRefGoogle ScholarPubMed
29. Gardner, PS, McQuillin, J, McGuckin, R: The late detection of RSV in cells of respiratory tract by immunofluorescence. J Hyg 1970; 68:575.Google Scholar
30. Smith, RA: Background and mechanisms of action of ribavirin, in Smith, RA, Knight, V, Smith, JAD (eds): Clinical Applications of Ribavirin. Orlando, Academic Press Inc, 1984, pp 1–18.Google Scholar
31. Hall, CB. Powell, KR, et al: RSV infection in children with compromised immune function. N Engl J Med 1986; 315:77–81.CrossRefGoogle ScholarPubMed
32. Hall, CB. Walsh, EE, et al: Ribavirin treatment of experimental RSV infection— 4 controlled double-blind study in young adults. JAMA 1983; 249(19):2666–2670.10.1001/jama.1983.03330430042027CrossRefGoogle Scholar
33. Hall, CB, McBride, JT, et al: Aerosolized ribavirin treatment of infants with RSV infection—A randomized double-blind study. N Engl J Med 1983; 308(24):t 143–t 147.CrossRefGoogle Scholar
34. Taber, LH, Knight, V, et al: Ribavirin aerosol treatment of bronchiolitis due to RSV infection in infants. Pediatrics 1983; 72:613–618.CrossRefGoogle ScholarPubMed
35. Hall, CB, McBride, JT, Gala, CL, et al: Ribavirin treatment of RSV infections in infants with underlying cardiopulmonary disease. JAMA 1985; 254:3047.CrossRefGoogle ScholarPubMed
36. Connor, JD, Van Dyke, R, Mintz, M, et al: Pharmacokinetics of ribavirin small particle aerosol therapy in children and adults. Abstract 932 of the 23rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Las Vegas. Oct. 24-26, 1983.Google Scholar
37. Connor, JD, Mintz, M, Van Dyke, K. et al: Ribavirin pharmacokinetics in children and adults during therapeutic trials, in Smith, K 4, Knight, V, Smith, JAI) (eds): Clinical Application of Ribavirin. Orlando, Academic Press, Inc, pp 107–123.Google Scholar
38. Brunell, PA, Daum, RS. et al (Committee on Infectious Diseases, 1986-1987): Ribavirin therapy of RSV. Pediatrics 1987; 79(3):475–478.Google Scholar