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Genetical control of the anaphylactoid reaction in rats

Published online by Cambridge University Press:  14 April 2009

J. M. Harris ,
H. Kalmus  and
G. B. West
J. M. Harris
Affiliation:
Department of Pharmacology, School of Pharmacy, Brighton College of Technology
H. Kalmus
Affiliation:
Galton Laboratory, University College, London
G. B. West
Affiliation:
Department of Pharmacology, School of Pharmacy, University of London
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1. A recessive autosomal gene, dx, preventing the anaphylactoid reaction has been discovered in a stock of Wistar albino rats from the Agricultural Research Council, Compton.

2. Segregation occurred in the F2 generation derived from crossing pure-bred reactor rats and pure-bred non-reactor rats.

3. Non-reactivity was outbred into non-albino stocks and was shown to segregate independently of the albino gene c and not to be closely linked to the colour genes, P and A.

4. The mutation from Dx to dx may have arisen a few years ago in one of the Wistar colonies before it was split into sub-lines.

5. The dx gene is fixed in several brother-sister mated sub-lines and appears to be in equilibrium with Dx in some less inbred closed-populations.

Information

Type
Research Article
Information
Genetics Research , Volume 4 , Issue 3 , November 1963 , pp. 346 - 355
Copyright
Copyright © Cambridge University Press 1963

References

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