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The effects of the t-complex upon male reproduction are due to complex interactions between its several regions

Published online by Cambridge University Press:  14 April 2009

Craig Hammerberg
Craig Hammerberg
Affiliation:
Department of Human Genetics, Box 015, The University of Michigan Medical School, 1137 E. Catherine Street, Ann Arbor, Michigan 48109
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Summary

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The three major regions (T, tail-determining; A, abnormal transmission ration; L, embryonic lethality) of the t complex on the murine seventeenth chromosome can interact to influence male reproduction (Lyon & Mason, 1977; Hammerberg, 1981). Evidence is presented here that suggests: (1) the presence of a polymorphic system within the T region that influences quasi-sterility in the male; (2) the existence of enhancing factors of transmission ratio distortion; and (3) that preferential interactions between t-haplotypes are found to occur both cis and trans which influence transmission ratio distortion.

Information

Type
Research Article
Information
Genetics Research , Volume 39 , Issue 3 , June 1982 , pp. 219 - 226
Copyright
Copyright © Cambridge University Press 1982

References

REFERENCES

Bennett, D. (1975). The t–locus of the mouse. Cell 6, 441–445.CrossRefGoogle Scholar
Bennett, D. & Dunn, L. C. (1960). A lethal mutation (t w18) in the house mouse showing partial duplications. Journal of Experimental Zoology 143, 203–219.CrossRefGoogle Scholar
Bennett, D. & Dunn, L. C. (1971). Transmission ratio distorting genes on chromosome IX and their interaction. In Proceedings, Symposium on the Immunogenetics of the H-2 System (ed. Lengerova, A. and Vojtiskova, M.), pp. 90–103. Basel: Karger.Google Scholar
Chesley, P. & Dunn, L. C. (1936). The inheritance of taillessness (anury) in the house mouse. Genetics 21, 525–536.CrossRefGoogle ScholarPubMed
Dunn, L. C. & Bennett, D. (1969). Studies of the effects of t–alleles in the house mouse on spermatozoa. II. Quasi-sterility caused by different combinations of alleles. Journal of Reproduction and Fertility 20, 239–246.CrossRefGoogle ScholarPubMed
Dunn, L. C. & Gluecksohn-Schoenheimer, S. (1943) Test for recombination amongst three lethal mutations in the house mouse. Genetics 28, 29–40.CrossRefGoogle Scholar
Erickson, R. P., Lewis, S. E. & Slusser, K. S. (1978). Deletion mapping of the t complex of chromosome 17 of the mouse. Nature 274, 163–164.CrossRefGoogle Scholar
Hammerberg, C. (1981). The influence of T orl upon male fertility in t–bearing mice. Genetical Research 37, 71–77.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Mason, I. (1977). Information on the nature of t–haplotypes from the interaction of mutant haplotypes in male fertility and segregation ratio. Genetical Research 29, 255–266.CrossRefGoogle Scholar
Silver, L. M., White, M. & Artzt, K. (1980). Evidence for possible unequal crossing over within the mouse T/t complex. Proceedings of the National Academy of Sciences, USA 77, 6077–6080.CrossRefGoogle Scholar